Protective prostaglandins for use in conjunction with chemothera

Details Protective prostaglandins for use in conjunction with chemothera Protective prostaglandins for use in conjunction with chemothera

1995-05-11

1996-11-26

Jordan, Kimberly

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514573, 514880, A61K 31215, A61K 3119, A61K 31557

Patent

active

055786405

ABSTRACT:
Prostaglandins of the PGE type can be administered in a therapeutically effective amount to protect tissue from injury resulting from chemotherapeutic agents by administering the PGE-type prostaglandin prior to administration of the chemotherapeutic agent.

REFERENCES:
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patent: 4254145 (1981-03-01), Birnbaum
patent: 5324746 (1994-06-01), McKee et al.
Potten, et al. "Hair Medullary Cell Counts-a simple and sensitive indicator of radiation exposure." Int. J. Radiat. Biol., 57, No. 1:13-21 (1990).
Jimenez, et al. "Biomedicine--Hair-Raising Adjunct for Chemotherapy." Science News, vol. 141:60 (1992).
Hussein, et al. "Protection from Chemotherapy-Induced Alopecia in a Rat Model." Science, vol. 249:1564-1566 (1990).
Jimenez, et al. "Protection from 1-B-D-Arabinofuranosylcytosine-Induced Alopecia by Epidermal Growth Factor." Cancer Research, vol. 52:413-415 (1992).
Torsher, et al. "Misoprostal Therapy Following Trinitrobenzene Sulfonic Acid-Induced Colitis-Accelerates Healing." CA, 116(23):228896W (1992).
Glover, et al. "Clinical Trials of WR-2721 Prior to Alkylating Agent Chemotherapy and Radiotherapy." Pharmac. Ther., vol. 39:3-7 (1988).

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