PLA.sub.2 inhibitors and their use for inhibition of intestinal

Details PLA.sub.2 inhibitors and their use for inhibition of intestinal PLA.sub.2 inhibitors and their use for inhibition of intestinal

1995-05-30

1996-11-26

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514539, 514562, 514567, 514568, 558414, 560 17, 560 21, 560 43, 562431, 562435, 562454, 562456, 562457, A61K 31195, A61K 31215, A61K 31275

Patent

active

055786391

ABSTRACT:
Certain compounds have been synthesized and found to be effective inhibitors of phospholipase A.sub.2 (PLA.sub.2), and thereby useful in the treatment of intestinal cholesterol absorption and the disease states arising therefrom, such as hypercholesterolemia and coronary artery disease.

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Arch Intern Med., vol. 153, pp. 1345-1353 (1993), Dressman et al.
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