Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1995-06-06
1997-02-25
Houtteman, Scott W.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
436501, 536 243, 536 266, 536 2532, C12Q 168
Patent
active
056058004
ABSTRACT:
Detection methods and compositions of matter comprising an enzyme coupled to a nucleic acid are disclosed. A complex of the enzyme-nucleic acid hybridized to a nucleic acid to be detected is also disclosed. The nucleic acid is detected by measuring the activity of the enzyme.
REFERENCES:
patent: 3654090 (1972-04-01), Schuurs et al.
patent: 3817837 (1974-06-01), Rubenstein et al.
patent: 3839153 (1974-10-01), Schuurs et al.
patent: 3850752 (1974-11-01), Schuurs et al.
patent: 3879262 (1975-04-01), Schuurs et al.
patent: 3880934 (1975-04-01), Rammler
patent: 4002532 (1977-01-01), Weltman et al.
patent: 4016043 (1977-04-01), Schuurs et al.
patent: 4067774 (1978-01-01), Rubenstein et al.
patent: 4134792 (1979-01-01), Boguslaski et al.
patent: 4139346 (1979-02-01), Rabbani
patent: 4228237 (1980-10-01), Hevey et al.
patent: 4318980 (1982-03-01), Boguslaski et al.
patent: 4358535 (1982-11-01), Falkow et al.
patent: 4442204 (1984-04-01), Greenquist et al.
patent: 4526871 (1985-07-01), Avrameas et al.
patent: 4581333 (1986-04-01), Kourilsky et al.
Kato et al., "New Technology For Enzyme Use," Chemistry and Organisms, 14(11): 737-744 (1976) and English translation.
Schuurs et al., Clinica Chimica Acta, 81:1-40 1977.
Broker et al., Nucleic Acids Res., 5(2):363-384 Feb. 1978.
Kato et al. "New Technology For Enzyme Use," Chemistry and Organisms, 14(11):737-744 (1976) and English translation.
Andres, G., et al., "Immunologic Techniques for the Identification of Antigens or Antibodies by Electron Microscopy," in Cellular Immunology (2d ed.), vol. 2, Weir (ed.), Blackwell Scientific Publications, Oxford, pp. 34.1-34.45 (1973).
Avrameas, S., "Coupling of Enzymes to Proteins with Glutaraldehyde. Use of the Conjugates for the Detection of Antigens and Antibodies," Immunochemistry 6:43-52 (1969).
Kourilsky, P., et al., "Hybridization on Filters with Competitor DNA in the Liquid Phase in a Standard and a Micro-Assay," Biochimie 56:1215-1221 (1974).
Avrameas, S., et al., "The Study of Lymphocyte Membranes Using Immunoenzymatic Techniques," in Immunofluorescence and Related Staining Techniques, Knapp et al. (eds.), Elsevier/North-Holland Biomedical Press, Amsterdam/New York, pp. 203-213 (1978).
Bauman, J., "Cytochemical Detection of Specific Nucleic Acid Sequences: Development and Application of In Situ Hybridization Methods For Fluorescence Microscopy," Drukkerij J. H. Pasmans b.v. 's Gravenhage (1980).
Bayer, E., et al., "Affinity Cytochemistry: The Localization of Lectin and Antibody Receptors on Erythrocytes Via the Avidin-Biotin Complex," FEBS Letters 68(2):240-244 (1976).
Sodja, A., Davidson, N., "Gene Mapping and Gene Enrichment by the Avidin-Biotin Interaction: Use of Cytochrome-C as a Polyamine Bridge," Nucleic Acids Research 5(2): 385-401 (1978).
Broker, T., et al., "Electron Microscopic Visualization of tRNA Genes with Ferritin-Avidin:Biotin Labels," Nucleic Acids Research 5(2):363-382 (1978).
Dale, R., et al., "Conversion of Covalently Mercurated Nucleic Acids to Tritiated and Halogenated Derivatives," Nucleic Acids Research 2(6): 915-930 (1975).
Dale, R., et al., "Direct Covalent Mercuration of Nucleotides and Polynucleotides," Biochemistry 14(11):2447-2457 (Apr.-Jun. 1975).
Dale, R., et al., "The Synthesis and Enzymatic Polymerization of Nucleotides Containing Mercury: Potential Tools for Nucleic Acid Sequencing and Structural Analysis," Proc. Nat. Acad. Sci. 70(8):2238-2242 (1973).
Heggeness, M., Ash J., "Use of the Avidin-Biotin Complex for the Localization of Actin and Myosin with Fluorescence Microscopy," J. Cell Biol. 73:783-788 (1977).
Heitzmann, H., Richards, F., "Use of the Avidin-Biotin Complex for Specific Staining of Biological Membranes in Electron Microscopy," Proc. Nat. Acad. Sci. 71(9):3537-3541 (1974).
Kohne, E., et al., "Room Temperature Method for Increasing the Rate of DNA Reassociation by Many Thousandfold: The Phenol Emulsion Reassociation Technique," Biochemistry 16(24):5329-5341 (1977).
Kraehenbuhl, J., et al., "Quantitative Immunocytochemistry at the Electron Microscope," in Immunofluorescence and Related Staining Techniques, Knapp et al. (eds.), Elsevier/North-Holland Biomedical Press, Amsterdam/New York pp. 245-253 (1978).
Mackey, J., et al., "Do Highly Oncogenic Group A Human Adenoviruses Cause Human Cancer? Analysis of Human Tumors for Adenovirus 12 Transforming DNA Sequences," Proc. Nat. Acad. Sci. 73(12):4657-4661 (1976).
Miller, G., et al., "Biological Properties and Viral Surface Antigens of Burkitt Lymphoma--and Mononucleosis-Derived Strains of Epstein-Barr Virus Released from Transformed Marmoset Cells," J. Virol. 18(3):1071-1080 (1976).
Molday, R., et al., "Latex Spheres as Markers for Studies of Cell Surface Receptors by Scanning Electron Microscopy," Nature 249:81-83 (1974).
Nakane, P., Wilson, M., "Cytochemical Localization of Poly-adenylic Acid (Poly A)," J. Cell. Biol. 67:302(a) (1975).
Nakane, P., Pierce, G., "Enzyme-Labeled Antibodies for the Light and Electron Microscopic Localization of Tissue Antigens," J. Cell Biol. 33:307-318 (1967).
Nakane, P., et al., "Peroxidase-Labeled Antibody: A New Method of Conjugation," J. Histochem. and Cytochem. 22(12): 1084-1091 (1974).
Reiser, J., et al., "Transfer of Small DNA Fragments from Polyacrylamide Gels to Diazobenzyloxymethyl-Paper and Detection by Hybridization with DNA Probes," Biochem. and Biophys. Res. Comm. 85(3):1104-1112 (1978).
Reitz, M., et al., "Primate Type-C Virus Nucleic Acid Sequences (Woolly Monkey and Baboon Types) in Tissues from a Patient with Acute Myelogenous Leukemia and in Viruses Isolated from Cultured Cells of the Same Patient," Proc. Nat. Acad. Sci. 73(6):2113-2117 (1976).
Rudkin, G., Stollar, B., "High Resolution Detection of DNA-RNA In Situ by Indirect Immunofluorescence," Nature 265:472-473 (1977).
Southern, E., "Detection of Specific Sequences Among DNA Fragments Separated by Gel Electrophoresis," J. Mol. Biol. 98(93):503-517 (1975).
Turler, H., "Interactions of Polyoma and Mouse DNAs, IV. Time Course and Extent of Integration of Polyoma DNA into Mouse DNA During Lytic Infection," J. Virol. 23(2):272-285 (1977).
Werner, B., et al., "Association of E Antigen with Dane Particle DNA in Sera from Asymptomatic Carriers of Hepatitis B Surface Antigen," Proc. Nat. Acad. Sci. 74(5):2149-2151 (1977).
Wilson, M., Nakane, P., "Recent Developments in the Periodate Method of Conjugating Horseradish Peroxidase (HRPO) to Antibodies," in Immunofluorescence and Related Staining Techniques, Knapp et al. (eds.), Elsevier/North-Holland Biomedical Press, Amsterdam, pp. 215-224 (1978).
Wisdom, G., "Enzyme-Immunoassay," Clinical Chemistry 22(8):1243-1255 (1976).
Yen, P., et al., "Sequence Arrangement of tRNA Genes on a Fragment of Drosophila melanogaster DNA Cloned in E. coli ," Cell 11:763-777 (1977).
Ames, B. N., et al., "Epoxides of Carcinogenic Polycyclic Hydrocarbons are Frameshift Mutagens," Science, 176: 47-49 (1972).
Avrameas, S., et al., "Peroxidase Labelled Antibody and Fab Conjugates with Enhanced Intracellular Penetration," Immunochemistry, 8:1175-1179 (1971).
Avrameas, S., et al., "Coupling of Enzymes to Antibodies and Antigens," Scand. J. Immunol., 8, Suppl. 7:7-23 (1978).
Bloomfield, V. A., et al., Physical Chemistry of Nucleic Acids, pp. 429-476 (Harper & Row, New York, 1974).
Cain, B. F., et al., "Potential Antitumor Agents. 28. Deoxyribonucleic Acid Polyintercalating Agents," Journal of Medicinal Chemistry, 21(7): 658-668 (1978).
Canellakis, E. S., et al., "Diacridines: Bifunctional Intercalators. I. Chemistry, Physical Chemistry And Growth Inhibitory Properties," Biochimica et Biophysica Acta, 418:277-289 (1976).
Dervan, P. B., et al., "Molecular Recognition of DNA by Small Molecules. Synthesis of Bis(methidium) spermine, a DNA Polyintercalating Molecule," Journal of the American Chemical Society, 100(6):1968-1970 (1978).
Dow, L. W., et al., "In Vitro Synthesis of DNA Components of Human Genes for Globin: Use as a Probe for Messenger RNA (mRNA)," Journal of Clinical Investigation, 51: 24a-25a (1972).
Dunn, A. R., et al., "A Novel Method to Map Transcripts: Evidence for Homol
Avrameas Stratis
Cami, born Contamine Brigitte
Guesdon Jean-Luc
Kourilsky Philippe
Houtteman Scott W.
Institut Pasteur
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