KGF receptor-derived antagonists of KGF binding

Details KGF receptor-derived antagonists of KGF binding KGF receptor-derived antagonists of KGF binding

1993-05-04

1996-11-26

Davenport, Avis M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 13, 514 14, 514 15, 530324, 530325, 530326, 530327, 530328, A61K 3800, C07K 500, C07K 700

Patent

active

055785662

ABSTRACT:
The invention provides KGFR peptides which inhibit binding between keratinocyte growth factor (KGF) and its receptor. The sequence of the peptides is derived from regions in the receptor which specifically bind the growth factor. Also provided are pharmaceutical compositions and methods of inhibiting the interaction of KGF and the receptor in a patient to treat various carcinomas.

REFERENCES:
patent: 3941763 (1976-03-01), Sarantakis
Ron et al., J. Biol. Chem., vol. 268 No. 4, 1993 pp. 2984-2988.
Finch, P. W., et al., "Human KGF Is FGF-Related with Properties of a Paracrine Effector of Epithelial Cell Growth", Science, 245:752-755 (18 Aug. 1989).
Miki, T., et al., "Expression cDNA Cloning of the KGF Receptor by Creation of a Transforming Autocrine Loop," Science, 251:72-75 (4 Jan. 1991).
Bottaro, D. P., et al., "Characterization of the Receptor for Keratinocyte Growth Factor," J. Biol. Chem., 265(22):12767-12770 (6 Aug. 1990).
Rubin, J. S, "KGF is a Paracrine Mediator of Epithelial Cell Growth," Proc. Amer. Assoc. Cancer Res., 34:588 (Mar. 1993).
Miki, T., et al., "Determination of ligand-binding specificity by alternative splicing: Two distinct growth factor receptors encoded by a single gene," Proc. Natl. Acad. Sci. USA, 89:246-250 (Jan. 1992).

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