Physiologically active peptide having immunoregulatory activitie

Details Physiologically active peptide having immunoregulatory activitie Physiologically active peptide having immunoregulatory activitie

1991-07-12

1995-11-07

Warden, Jill

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 17, 514 18, 514 19, 530329, 530330, 530331, A61K 3800, C07K 500, C07K 700, C07K 1700

Patent

active

054648190

ABSTRACT:
A novel, substantially pure, physiologically active peptide is disclosed, comprising an amino acid sequence selected from Gly-Glu (SEQ ID NO. 5), Pro-Val-Val (SEQ ID NO. 6), Glu-Pro-Val-Val (SEQ ID NO. 7), Glu-Glu-Pro-Val-Val (SEQ ID NO. 8), Ala-Glu-Glu-Pro-Val-Val (SEQ ID NO. 9), and Gly-Ala-Glu-Glu-Pro-Val-Val (SEQ ID NO. 10). This peptide has immunoregulatory activities, including the activity to inhibit multiplication of Toxoplasma gondii inside cells, antibacterial activity, antiviral activity and antitumor activity. A composition comprising at least two peptides selected from the above peptides or comprising at least one peptide selected from the above peptides and at least one additional peptide comprising an amino acid sequence selected from Gly-Glu-Glu-Glu-Glu-Glu (SEQ ID NO. 1), Glu-Glu-Glu-Glu-Glu (SEQ ID NO. 2), Asp-Asp-Asp-Asp-Asp (SEQ ID NO. 3) and Ala-Glu-Glu-Glu-Glu-Glu (SEQ ID NO. 4) is especially useful as an active component for antiprotozoan, antibacterial, antiviral or antitumor agent.

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