Drug loaded polymeric material and method of manufacture

Details Drug loaded polymeric material and method of manufacture Drug loaded polymeric material and method of manufacture

1995-03-30

1997-02-25

Azpuru, Carlos

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424501, 264 43, 623 1, A61F 202, A61F 206, A61K 950, B01J 1302

Patent

active

056056966

ABSTRACT:
The drug loaded polymeric material containing a therapeutic drug can be applied to a structure of an intravascular stent. A therapeutically effective amount of a therapeutic drug is incorporated into such a layer of polymeric material, without significantly increasing the thickness of the stent, to avoid interfering with the function of the stent. The drug loaded polymer coating of the stent can formed to include pores, can be multi-layered to permit the combination of a plurality of different drug containing materials in a single stent, and can include a rate controlling membrane to allow for controlled retention and delivery of selected drugs within the affected blood vessel upon implantation. The layer of polymeric material is manufactured by combining the selected polymeric material with a relatively high loading of the therapeutic drug in a thermal process, such as coextrusion of the therapeutic drug with the polymeric material. The therapeutic drug is dispersed and incorporated into the polymer as small particles, preferably having a maximum cross-sectional dimension of 10 microns.

REFERENCES:
patent: 4299613 (1981-11-01), Cardarelli
patent: 4346028 (1982-08-01), Griffith
patent: 4400374 (1983-08-01), Cardarelli
patent: 4441215 (1984-04-01), Kaster
patent: 4633873 (1987-01-01), Dumican et al.
patent: 4718907 (1988-01-01), Karwoski et al.
patent: 4768507 (1988-09-01), Fischell et al.
patent: 4879135 (1989-11-01), Greco et al.
patent: 4902290 (1990-02-01), Fleckenstein et al.
patent: 5059211 (1991-10-01), Stack et al.
patent: 5062829 (1991-11-01), Pryor et al.
patent: 5084065 (1992-01-01), Weldon et al.
patent: 5085755 (1992-04-01), Daniels et al.
patent: 5104403 (1992-04-01), Brotzu et al.
patent: 5156623 (1992-10-01), Hakamatsuka et al.
patent: 5163951 (1992-11-01), Pinchuk et al.
patent: 5180366 (1993-01-01), Woods
patent: 5197977 (1993-03-01), Hoffman, Jr. et al.
patent: 5234456 (1993-08-01), Silvestrini
patent: 5234457 (1993-08-01), Anderson
patent: 5236447 (1993-08-01), Kubo et al.
patent: 5279594 (1994-01-01), Jackson
patent: 5290271 (1994-03-01), Jernberg
patent: 5342348 (1994-08-01), Kaplan
patent: 5342621 (1994-08-01), Eury
patent: 5356433 (1994-10-01), Rowland et al.
patent: 5380299 (1995-01-01), Fearmot e tal.
patent: 5383925 (1995-01-01), Schmitt
patent: 5385580 (1995-01-01), Schmitt
Eury, Chemical Abstracts, vol. 121, #7810, 1993.
Eury, Chemical Abstracts, vol. 121, #213062, 1992.
"Totally Resorbable High-Strength Composite Material," by Benjamin S. Kelley, Richard L. Dunn and Robert A. Casper, Advances in Biomedical Polymers Edited by Charles G. Gebelein.
"A View of Vascular Stents" by Richard A. Schatz, M.D. from the Arizona Heart Institute Foundation, Phoenix, Arizona (1988).
"Fiber-Reinforced Absorbable Composite for Orthopedic Surgery" by R. A. Casper, B. S. Kelley, R. L. Dunn, A. G. Potter, and D. N. Ellis in Polymeric Materilas Science and Engineering, Proceedings of the ACS DivisiofPlyei Mtra: Science and Engineering, vol. 53, Fall Meeting 1985.

Affiliated with

Also associated with

Rating

Drug loaded polymeric material and method of manufacture does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Drug loaded polymeric material and method of manufacture, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Drug loaded polymeric material and method of manufacture will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1972671