Immunologically active proteins from inclusion bodies

Details Immunologically active proteins from inclusion bodies Immunologically active proteins from inclusion bodies

1993-09-29

1997-02-25

Mosher, Mary E.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

530412, 530413, 435 691, 435 693, A61K 3900, C07K 114, C07K 122

Patent

active

056056915

ABSTRACT:
This invention relates to the conversion of denatured proteins to soluble forms which are suitable for injection of humans and other animals. The invention is also suitable for analytical use. This method is applicable to the efficient solubilization of proteins which have varying degrees of solubility.

REFERENCES:
patent: 4511502 (1985-04-01), Builder et al.
patent: 4511503 (1985-04-01), Olson et al.
patent: 4512922 (1985-04-01), Jones et al.
patent: 4518526 (1985-05-01), Olson
patent: 4604377 (1986-08-01), Fernandes et al.
patent: 4677196 (1987-06-01), Rausch et al.
patent: 4678553 (1987-07-01), Mandle et al.
patent: 4735800 (1988-04-01), Collett et al.
patent: 4766224 (1988-08-01), Rausch
patent: 4801691 (1989-01-01), Auer
patent: 4931543 (1990-06-01), Halenbeck et al.
patent: 5019508 (1991-05-01), Johnson et al.
patent: 5101018 (1992-03-01), Mehrotra et al.
patent: 5109121 (1992-04-01), Blum et al.
patent: 5196193 (1993-03-01), Carroll
Ausubel, F. M. et al. 1988. Current Protocols in Molecular Biology vol. 2.
John Wiley & Sons, New York, pp. 10.2.1-10.2.9 and 10.5.1-10.5.5.
Edens, R. E. et al. 1990. J. Immunol. Meth. vol. 133 pp. 67-70.
Neugebauer, J. M. 1990, "Detergents: an overview", Methods Enzymol vol. 182 pp. 239-253.
Knuth, M. W. et al. 1987. "Purification of Proteins in the Denatured State". Protein Purification: Micro to Macro, ed. R. Burgess, Alan R. Liss, NY, pp. 297-305.
Weber, K., and M. Osborn. In: The Proteins, ed. H. Neurath, Academic Press, New York. vol. 1, pp. 179-223.
Jaenicke, R, and R. Rudolph. In: Protein Structure, a Practical Approach, ed. T. E. Creighton, IRL Press, Oxsford, pp. 191-223.
F. A. O. Marston, Biochem. J. 240:1 (1986).
C. H. Schein, Biotechnology 7:1141 (1989).
Bruggemann et al., BioTechniques 10:202 (1991).
D. L. Wilkinson and R. G. Harrison, Biotechnology 9:443 (1991).
F. A. O. Marston, In: DNA Cloning: A Practical Approach, vol. III (D. Glover, ed.) (IRC Press) (1989) pp. 59.
J. Krueger et al., BioPharm. 2:40 (1989).
Soutschek et al., J. of Chrom. 521:267 (1990).
A. C. Issekutz, J. of Immunological Methods 61:275 (1983).
Rosenberg et al., Gene 56:125 (1987).
A. S. Laughon, and M. P. Scott, Nature 310:25 (1984).
F. W. Studier et al., Methods of Enzymology 185:60 (1990).
B. S. Thalley and S. B. Carroll, BioTechnology 8:934 (1990).
H. Towbin et al., Proc. Natl. Acad. Sci. USA 76:4350 (1979).
S. Carroll and M. P. Scott, Cell 43:47 (1985).
D. Tautz, Nature 332:281 (1988).
J. Pankratz et al., Cell 61:309 (1990).
U. Gaul et al., Cell 50:639 (1987).
R. Kraut and M. Levine, Development 111:601 (1991).
O. Kapp and S. Vinogradov, Anal. Biochem. 91:230 (1978).
G. Tuszynski and L. Warren, Anal. Biochem. 67:55 (1975).
S. B. Carroll and A. S. Laughon, In: DNA Cloning: A Practical Approach, vol. III, Production and Purification of Polyclonal Antibodies to the Foreign Segment of .beta.-galactosidase Fusion Proteins (D. Glover, ed.) (IRL Press Oxford) (1987), pp. 89-111.
K. Talmadge and C. Siebert, J. Chromatography 476:175 (1989).
D. Rifkind and J. Palmer, J. Bacter. 92:815 (1966).

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