Intermediates in the preparation of chiral spirofluorenehydantoi

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters

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560 34, 560 45, 560 47, 560 48, C07C32100, C07C22900

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active

051515440

ABSTRACT:
Disclosed is a process for the synthesis of enantiomerically pure R and S isomers of 2,7-difluoro-4-methoxyspiro[9H-fluorene-9,4-imidazolidene]-2',5'-dione from 2,7-difluoro-4-methoxyfluorenone. Intermediate amino acid esters and urea esters and their preparation are also described.

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Sarges, et al., "Synthesis of Optically Active Spirohydantoins by Asymmetric Induction. Hydantoin Formation from Amino Nitriles and Chlorosulfonyl Isocyanate", J. Org. Chem:47(21) 4081-4085 (1982).
Okamoto, et al., "Controlled Chiral Recognition of Cellulos Triphenylcarbamate Derivatives Supported on Silica Gel", J. Chromatography:363, 173-186(1986).

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