Synthesis of 3-amino-2-chloro-4-methylpyridine from acetone and

Details Synthesis of 3-amino-2-chloro-4-methylpyridine from acetone and Synthesis of 3-amino-2-chloro-4-methylpyridine from acetone and

2000-01-06

2000-10-24

McKane, Joseph

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D21372

Patent

active

061369829

ABSTRACT:
A method for making 3-amino-2-chloro-4-methylpyridine from acetone and ethyl cyanoacetate, as depicted in the following reaction scheme. ##STR1##

REFERENCES:
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Norman et al. Structural Elucidation of an Oxazolo[5,4-b]pyridine: an Alternative Cyclization Product Related to Nevirapine, J. Heterocyclic Chem., 30, 771-779, 1993.
Klunder et al. Novel Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase. 2. Tricyclic Pyridobenzoxazepinones and Dibenzoxazepinones J. Med. Chem. 35:1887-1897, 1992.
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Grozinger, et al; J. Heterocyclic Chem., 32, 259; 1995.
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Hargrave, et al; J. Heterocyclic Chem., 34, 223; 1991.

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