Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1998-04-02
2000-10-24
Low, Christopher S. F.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530350, 435 6, 435 691, 435 922, 536 231, 536 235, 536 255, 514 44, 514 2, 935 23, 424 9321, C07K 14435
Patent
active
061369535
ABSTRACT:
A substantially pure DNA comprising a sequence encoding a smooth muscle cell LIM (SmLIM) polypeptide, methods of diagnosing vascular injury by detecting a decrease in SmLIM gene expression, and methods of inhibiting vascular smooth muscle cell proliferation.
REFERENCES:
Weiskirchen et al. Direct Submission to the EMBL Data Library, May 8, 1995.
Weiskirchen et al. Oncogene, vol. 8, pp. 2317-2324, Apr. 16, 1993.
Arber et al. "Muscle LIM Protein a Novel Essential Regulator of Myogenesis, Promotes Myogenic Differentiation", Cell, 79:221-31 (1994).
Crawford et al. "Biochemical and Molecular Characterization of the Chicken Cysteine-rich Protein, a Developmentally Regulated LIM-Domain Protein That Is Associated with the Actin Cytoskeleton", J. Cell. Biol., 124:117-27 (1994).
Hillier et al. GenBank Accession #N39473, Jan. 19, 1996.
Libby et al. "Biology of Disease: Involvement of the Immune System in Human Atherogenesis: Current Knowledge and Unanswered Questions", Lab. Investig., 64:5-15 (1991).
Munro et al., "Biology of Disease: The Pathogenesis of Atherosclerosis: Atherogenesis and Inflammation", Lab. Invest., 58:249-61 (1988).
Ross, "The Pathogenesis of Atherosclerosis: a Perspective for the 1990s", Nature, 362:801-809 (1993).
Sadler et al., "Zyxin and cCRP: Two Interactive LIM Domain Proteins Associated with the Cytoskeleton", J. Cell. Biol., 119:1573-87 (1992).
Tsai et al. "Promotion of Vascular Smooth Muscle Cell Growth by Homocysteine: A Link to Atherosclerosis", PNAS USA, 91:6369-73 (1994).
Tsai et al., "Induction of Cyclin A Gene Expression by Homocysteine in Vascular Smooth Muscle Cells", J. Clin. Invest., 97:146-53 (1996).
Wang et al., "Analysis of the Human Cysteine-Rich Protein Gene (CSRP) Assignment to Chromosome 1q24-1q32, and Identification of an Associated Mspl Polymorphism", Genomics, 14:391-97 (1992).
Wang et al. "Human Cysteine-rich Protein: A Member of the Lim/Double-Finger Family Displaying Coordinate Serum Induction with c-myc", J. Biol. Chem., 267:9176-84 (1992).
Warren et al., "The Oncogenic Cysteine-Rich LIM Domain Protein Rbtn2 is Essential for Erythroid Development" Cell, 78:45-57 (1994).
Weiskirchen et al., "The Cysteine-rich Protein Family of Highly Related LIM Domain Proteins", J. Biol. Chem. 270:28946-54 (1995).
Weiskirchen et al. "Suppression in transformed avian fibroblasts of a gene (crp) encoding a cysteine-rich protein containing LIM domains", Oncogene, 8:2317-2324 (1993).
Haber Edgar
Jain Mukesh
Lee Mu-En
Yet Shaw-Fang
Beattie Ingrid A.
Elrifi Ivor R.
Low Christopher S. F.
President and Fellows of Harvard College
Robinson Hope A.
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