Process for the production of phenol derivatives

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters

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560111, C07C 9678

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057568162

ABSTRACT:
A process for the production of a phenol derivative of the formula (2), which comprises subjecting a diester compound of the formula (1) in which a hydroxyl group is protected by an acyl group, to a reaction for removal of protection, wherein the reaction is carried out in the presence of an aliphatic amine as a protection-removal agent, ##STR1## wherein X is hydrogen or fluorine, Y is --CH.sub.3 or --CF.sub.3, Q is an alkyl group having 1 to 4 carbon atoms, p is 0 or 1, m is an integer of 2 to 7, n is an integer of at least 1, and C* is an asymmetric carbon,
the process enabling to obtain the phenol derivative of the formula (2) useful as an intermediate for a liquid crystal compound with ease and at high purity.

REFERENCES:
"Protective Groups in Organic Synthesis" Greene 1991 pg. 88-90 Pub. John Wiley & Sons.
"Advanced Organic Chemistry" Jerry March 1968 338-339.
CA 119:282389-AB578F JP 05163208 Jun. 29, 1993 Iwane, Prep. of Biphenyl Carboxylates.
Manuals for Organic Chemical Experiments, Synthesis Reactions II, 15, pp. 14-15.

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