Methods for identifying useful T-PA mutant derivatives for treat

Details Methods for identifying useful T-PA mutant derivatives for treat Methods for identifying useful T-PA mutant derivatives for treat

1999-09-02

2000-10-24

Dees, Jose' G.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 692, 4351721, 435226, 436 86, 514 2, G01N 3353, G01N 3300, C12N 1509, C12N 964, A01N 3718

Patent

active

061365483

ABSTRACT:
Methods for preventing or treating vascular hemorrhaging such as that incident to thrombolytic therapy, or characteristic of Alzheimer's and related diseases are provided. Such methods provide improved thrombolytic therapy to individuals who receive such therapy, and permit the diagnosis and treatment of diseases, such as Alzheimer's Disease, that are characterized by the deposition of amyloid deposits.

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patent: 5366886 (1994-11-01), Anderson et al.
Stewart, et al., "Characterization of the interactions of plasminogen and tissue and vampire bat plasminogen activators with fibrinogen, fibrin, and the complex of D-dimer noncovalently linked to fragment E", J. Biol. Chem., 1998 273; 18292-18299.
Kingston, et al., In vitro stimulation of tissue-type plasminogen activator by Alzheimer amyloid .beta.-peptide analogues, 1995 Nature Medicine 1(2); 138-142.
Merkle, et al., "Modulation of fibrin assembly and polymerization by the .beta.-amyloid of Alzheimer's disease" 1996 Blood Coagulation and Fibronolysis 7(6); 650-658.

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