Methods for treatment and prevention of drug-induced pruritus wi

Details Methods for treatment and prevention of drug-induced pruritus wi Methods for treatment and prevention of drug-induced pruritus wi

1996-12-30

1998-05-26

Cook, Rebecca

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514305, 514397, A61K 3144

Patent

active

057565147

ABSTRACT:
Methods of treating and preventing drug-induced pruritus in patients by administration of a serotonin type 3 antagonist are provided.

REFERENCES:
Crighton et al, Anaesthesia, 51(2), pp. 199-200, Feb. 1996.
Biosis AN 94:536734 Heim et al, Anaesthesist, 43(8), pp. 504-509, 1994.
Schworer et al, Clin. Investig, 71:659-662, 1993.
Naylor et al, Eur J Anaesthesiology, 9(Sup 6):3-10, 1992.
Gyermek, J Clin Pharmacol, 35:845-855, 1995.
Oxford et al, Progress in Medicinal Chem, vol. 29:239-270, 1992.
Schworer, H. and Ramadori, "Improvement of cholestatic pruritus by ondansetron", Lancet 1993 341:1277.
Schworer et al., "Relief of cholestatic pruritus by a novel class of drugs: 5-hydroxytryptamine type 3 (5-HT.sub.3) receptor antagonists: effectiveness of ondansetron", Pain 1995 61(1):33-37.

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