Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-12-06
1998-05-26
Tsang, Cecilia J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 9, 514 18, 530330, C07K 512
Patent
active
057564523
ABSTRACT:
A peptide containing the tripeptide recognition sequences RGD or KGD in a cycle and an exocyclic group bearing a positive charge is provided. The compound is provided in therapeutic form for administration to a mammal and exhibits high specificity and potency as a platelet aggregation inhibitor without undesireable side effects.
REFERENCES:
patent: 4517686 (1985-05-01), Rouslahti
patent: 4578079 (1986-03-01), Rouslahti
patent: 4589881 (1986-05-01), Pierschbacher
patent: 4614517 (1986-09-01), Rouslahti
patent: 4661111 (1987-04-01), Rouslahti
patent: 4683291 (1987-07-01), Zimmerman et al.
patent: 4792525 (1988-12-01), Rouslahti
patent: 4857508 (1989-08-01), Adams
patent: 4879313 (1989-11-01), Tjoeng et al.
patent: 5023233 (1991-06-01), Nutt et al.
patent: 5037808 (1991-08-01), Tjoeng et al.
patent: 5041380 (1991-08-01), Ruoslathi et al.
patent: 5395609 (1995-03-01), Stuttle
patent: 5493007 (1996-02-01), Burniel et al.
patent: 5643872 (1997-07-01), Ali et al.
Ali et al. Peptides Proc. (11th American Peptide Symposium, Jul. 9-14, 1989), Marshall and Rivier (eds.), La Jolla, CA (1989).
Bagdy et al., "In vitro Inhibition of Blood Coagulation by Tripeptide Aldehydes--A retrospective Screening Focused on the Stable D-MePhe-Pro-Arg-H-H2SO4" Thrombosis and Haemostasis 67(3):325-330 (1992).
Bond et al., "Amino Acid Sequence of Bovine Angiogenin" Biochemistry 28:6110-6113 (1989).
Chao et al., "Agkistrodon piscivorus piscivorus platelet aggregation inhibitor: a potent inhibitor of platelet activation" Proc. Natl. Acad. Sci. USA 86(20):8050-8054 (1989).
D'Souza et al., "Chemical cross-linking of arginyl-glycyl-aspartic acid peptides to an adhesion receptor on platelets" Journal of Biological Chemistry 263(8):3943-3951 (Mar. 1988).
Davies et al., "Synthetic peptide mimics of the active domain of fibronectin" Biochemical Society Transactions 18:1326-1328 (1990).
Dennis et al., "Platelet glycoprotein IIb-IIIa protein antagonists from snake venoms: Evidence for a family of platelet-aggregation inhibitors" Proc. Natl. Acad. Sci. USA 87:2471-2475 (1989).
Drickamer et al., "Mannose-binding proteins isolated from rat liver contain carbohydrate-recognition domains linked to collagenous tails. Complete primary structures and homology with pulmonary surfactant apoprotein" Journal of Biological Chemistry 261(15):6878-6887 (May 25, 1986).
Edwards, et al., "In vitro activity profiles of cyclic and linear enkephalin pseudopeptide analogs" Biochem. & Biophys. Res. Comm. 136(2):730-736 (Apr. 29, 1986).
Gan et al., "Echistatin: A potent platelet aggregation inhibitor from the venom of the viper Echis carinatus" Journal of Biological Chemistry 263:19827-19832 (1988).
Gardner, et al., "Interaction of fibronectin with its receptor on platelets" Cell 42(2):439-448 (Sep. 1985).
Garsky et al., "Chemical synthesis of echistatin, a potent inhibitor of platelet aggregation from Echis carinatus: Synthesis and biological activity of selected analogs" Proc. Natl. Acad. Sci. USA 86:4022-4026 (1989).
Gartner et al., "The tetrapeptide analogue of the cell attachment site of fibronectin inhibits platelet aggregation and fibrinogen binding to activated platelets" Journal of Biological Chemistry 260(22):11891-11894 (Oct. 5, 1985).
Gero, et al., "Synthesis and biological activity of a cyclic pseudohexapeptide analog of somatostatin" Biochem. & Biophys. Res. Comm. 120(3):840-845 (May 16, 1984).
Ginsberg, et al., "Inhibition of fibronectin binding to platelets by proteolytic fragments and synthetic peptides which support fibroblast adhesion" Journal of Biological Chemistry 260(7):3931-3936 (Apr. 10, 1985).
Haskel et al., "Deaggregation of human platelets in vitro by an rgd anaolg antagonist of platelet glycoprotein IIb/IIIa Receptors" Thrombosis Research 56:687-695 (1989).
Haverstick et al., "Inhibition of platelet adhesion to fibronectin, fibrinogen, and von Willebrand factor substrates by a synthetic tetrapeptide derived from the cell-binding domain of fibronectin" Blood 66(4):946-952 (Oct. 1985).
Huang et al., "Trigramin. A low molecular weight peptide inhibiting fibrinogen interaction with platelet receptors expressed on glycoprotein IIb-IIIa complex" Journal of Biological Chemistry 262(33):16157-16163 (Nov. 25, 1987).
Huang TF et al., "Trigramin: primary structure and its inhibition of von Willebrand factor binding to glycoprotein IIb/IIIa complex on human platelets" Biochemistry 28(2):661-666 (1989).
Joubert et al., "Some properties and the complete primary structures of two reduced and S-carboxymethylated polypeptides (S5C1 and S5C10) from Dendroaspis jamesoni kaimosae (Jameson's mamba) venom" Biochimica et Biophysica Acta 579(1):228-233 (Jul. 25, 1979).
Kieffer et al., "Platelet Membrane Glycoproteins: Functions in Cellular Interactions" Annu. Rev. Cell Biol. 6:329-357 (1990).
Kirchhofer et al., "Cation-dependent Changes in the Binding Specificity of the Platelet Receptor GPIIb/IIIa" Journal of Biological Chemistry 265(30):18525-18530 (1990).
Kloczewiak et al., "Platelet receptor recognition site on human fibrinogen. Synthesis and structure-function relationship of peptides corresponding to the carboxy-terminal segment of the gamma chain" Biochemistry 23(8):1767-1774 (Apr. 10, 1984).
Lash et al., "Synthetic peptides that mimic the adhesive recognition signal of fibronectin: differential effects on cell--cell and cell-substratum adhesion in embryonic chick cells" Developmental Biology 123(2):411-420 (Oct. 1987).
Maes et al., "The complete amino acid sequence of bovine milk angiogenin" Fed. Europ. Biochem. soc. 241:41-45 (1988).
Moos et al., "Neural adhesion molecule L1 as a member of the immunoglobulin superfamily with binding domains similar to fibronectin" Nature 334(6184):701-703 (Aug. 1988).
Neurath et al., "Confronting the hypervariability of an immunodominant epitope eliciting virus neutralizing antibodies from the envelope glycoprotein of the human immunodeficiency virus type 1 (HIV-1)" Mol-Immunol 27(6):539-549 (Jun. 1990).
Parise et al., "Synthetic peptides derived from fibrinogen and fibronectin change the conformation of purified platelet glycoprotein IIb-IIIa" Journal of Biological Chemistry 262(26):12597-12602 (Sep. 15, 1987).
Pierschbacher et al., "Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule" Nature 309(5963):30-33 (May 1984).
Pierschbacher et al., "Variants of the cell recognition site of fibronectin that retain attachment-promoting activity" Proc. Natl. Acad. Sci. USA 81(19):5985-5988 (Oct. 1984).
Plow et al., "Arginyl-glycyl-aspartic acid sequences and fibrinogen binding to platelets" Blood 70(1):110-115 (Jul. 1987).
Plow, et al., "The effect of Arg-Gly-Asp-containing peptides on fibrinogen and von Willebrand factor binding to platelets" Proc. Natl. Acad. Sci. USA 82:8057-8061 (1985).
Pytela et al., "A 125/115-kDA cell surface receptor specific for vitronectin interacts with the arginine-glycine-aspartic acid adhesion sequence derived from fibronectin" Proc. Natl. Acad. Sci. USA 82(17):5766-5770 (Sep. 1985).
Pytela et al., "Identification and isolation of a 140 kd cell surface glycoprotein with properties expected of a fibronectin receptor" Cell 40(1):191-198 (1985).
Pytela et al., "Platelet Membrane Glycoprotein IIb/IIIa: Member of a Famly of Arg-Gly-Asp-Specific Adhesion Receptors" Science 231:1559-1562 (1986).
Ratner et al., "Complete nucleotide sequence of the AIDS Virus, HTLV-III" Nature 313:277-284 (1984).
Rauvala et al., "The adhesive and neurite-promoting molecule p30: analysis of the amino-terminal sequence and production of antipeptide antibodies that detect p30 at the surface of neuroblastoma cells and of brain neurons" Journal of Cell Biology 107(6 Pt. 1):2293-2305 (Dec. 1988).
Ruggeri, et al., "Inhibition of platelet function with synthetic peptides designed to be high-affinity antagonists of fibrinogen binding to platelets" Proc. Natl. Acad. Sci. USA 83(15):5708-5712 (Aug. 1986).
Ruoslahti, "Integrins" J. Clin. Invest. 87:1-5 (1991).
Shebuski et al., "Characterization and Platelet Inhibitory Activity of Bitistatin, a Potent Arginine
Burnier John P.
Gadek Thomas
McDowell Robert S.
Delaney Patrick R.
Genentech Inc.
Tsang Cecilia J.
Winter Daryl B.
LandOfFree
Platelet aggregation inhibitors having high specificity for GP I does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Platelet aggregation inhibitors having high specificity for GP I, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Platelet aggregation inhibitors having high specificity for GP I will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1960022