Arylmethylphosphonates and phosphonic acids useful as anti-infla

Details Arylmethylphosphonates and phosphonic acids useful as anti-infla Arylmethylphosphonates and phosphonic acids useful as anti-infla

1995-03-16

1996-03-19

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514 76, 514129, 514141, A61K 3166, A61K 31675, A61K 31685

Patent

active

055004172

ABSTRACT:
This invention provides a new use of acids, esters, and salts of arylmethylphosphonates of Formula I, ##STR1## or phosphonic acid derivatives of Formula II ##STR2## as anti-inflammatory and anti-arthritic agents. Representative compounds include 4-dodecyloxybenzylphosphonic acid dimethyl ester, (2-naphthalenylmethyl)phosphonic acid dimethyl ester, and ([1,1 '-biphenyl]-2-ylmethyl)phosphonic acid dimethyl ester. The invention also provides novel acids, esters, and salts of arylmethylphosphonic acid, phosphonic acid and derivatives.

REFERENCES:
patent: 4822780 (1989-04-01), Tsuda et al.
Okazaki, M. et al. Chemical Abstracts, vol. 89, No. 24537 (1978); JP53 003 536, published Jan. 1978.

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