Human carbonyl reductase

Details Human carbonyl reductase Human carbonyl reductase

1996-12-09

1998-05-26

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435190, 4353201, 4353523, 435325, 538232, C12Q 168, C12N 1553, C12N 904

Patent

active

057562997

ABSTRACT:
The present invention provides a human carbonyl reductase (HCRD) and polynucleotides which identify and encode HCRD. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HCRD and a method for producing HCRD. The invention also provides for agonists, antibodies, or antagonists specifically binding HCRD, and their use, in the prevention and treatment of diseases associated with expression of HCRD. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HCRD for the treatment of diseases associated with the expression of HCRD. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HCRD.

REFERENCES:
Nakanishi, M., et al., "Cloning and Sequence Analysis of a cDNA Encoding Tetrameric Carbonyl Reductase fo PIG Lung," Biochem. Biophys. Acta 194(3):1311-16, 1993 (GI 416425).
Isselbacher k.J. et al., "Eicosanoids and Human Disease" Harrison's Principles of Internal Medicine, McGraw-Hill, New York City, vol. 1:431-435, 1994.
Soldan, M. et al., "Induction of Daunorubicin Carbonyl Reducing Enzymes by Daunorubicin in Sensitive and Resistant Pancreas Carcinoma Cells," Biochem. Pharmacol. 51:117-123, 1996.
Gonzalez, B. et al., "Protection against Daunorubicin Cytotoxicity by Expression of a Cloned Human Carbonyl Reductase cDNA in K562 Leukemia Cells," Cancer Res. 55:4646-4650, 1995.
Forrest, G.L. et al., "Induction of a human carbonyl reductase gene located on chromosome 21," Biochim. Biophys. Acta 1048: 149-155, 1990.
Navre, M., et al., A Growth Factor-repressible Gene Associated with Protein Kinase C-mediated Inhibition of Adipocyte Differentiation, The Journal of Cell Biology, 107:279-286, 1988 (GI 50004).
Wermuth, B., et al., "Human Carbonyl Reductase," The Journal of Biological Chemistry, 263(31):16185-16188, 1988 (GI 118519).

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