Personal care formulations

Details Personal care formulations Personal care formulations

1993-11-23

1996-03-19

Venkat, Jyothsna

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Cosmetic, antiperspirant, dentifrice

424 59, 424 64, 424 65, 424 701, 424 707, 424 73, 514844, 514845, 514846, 514847, 514937, 514938, 514939, 514944, A61K 748, A61K 7032, A61K 7027, A61K 7075

Patent

active

055002170

DESCRIPTION:

BRIEF SUMMARY
This application is a 371 of PCT/GB92/001 91 filed on Feb. 3, 1992.
The present invention relates to compositions which can be used in personal care applications and, in particular, to such compositions which contain an agent for protection against micro-organisms.
Compositions which may be used in personal care applications are of many types but are, in general, oil-in-water or water-in-oil emulsions. Many of these compositions are applied to the skin and may be, at least partially, absorbed by the skin. Such compositions include, inter alia, hand lotions, foundation creams, emollient creams, facial washing creams, shaving creams, after-shave lotions, sunscreen lotions and creams, sunscreen hair protectors, after sun lotions, antiperspirants, deodorants, hair gels, hair colourants and hair mousse. Other compositions which may be applied to the skin include various make-up formulations such as mascara, eye shadow, eyeliners, lipstick, lip gloss, facial blushes, rouges, foundations and fragrances. Most of the foregoing compositions are applied for long term contact with the skin. Other personal care products are used in a manner in which they make only temporary contact with the skin such as shampoos, shampoo gels, conditioning rinses, toothpaste, mouthwashes, foam bath liquids, miscible and soluble bath oils and liquid soap formulations. Many compositions which can be used in personal care applications are susceptible to the growth of micro-organisms and it is desirable to incorporate into these compositions a material which is effective to inhibit the growth of micro-organisms. However, many materials which possess anti-microbial activity either possess a satisfactory anti-microbial activity together with undesirable side effects or, if they have few or no side effects, show a low activity against micro-organisms.
We have now found that certain thiohydroxamic acid derivatives have useful anti-microbial activity and do not show appreciable undesirable side effects.
According to the present invention there is provided a personal care formulation which contains an anti-microbial agent wherein the anti-microbial agent is a compound of the general formula (I): ##STR1## or a complex or salt thereof; wherein: acyl group, a substituted acyl group or a group --COOR.sup.3 ; R.sup.1 and R.sup.2, together with the nitrogen and carbon atoms to which they are attached, form a heterocyclic ring; and
It is preferred that when R.sup.1 and R.sup.2, together with the nitrogen and carbon atoms to which they are attached, form a heterocyclic ring the heterocyclic ring contains at least two heteroatoms.
In the compound of general formula I, the groups R.sup.1 and R.sup.2 may be the same or different, but are preferably different. When any one or more of R, R.sup.1 and R.sup.2 is a substituted hydrocarbyl group, the substituent group is, or contains, at least one halogen atom such as fluorine, chlorine or bromine or contains at least one hetero atom selected from nitrogen, oxygen or sulphur as in the groups hydrocarbonoxy, hydrocarbonthio, acyl (that is hydrocarboncarbonyl), ester (that is acyloxy), hydrocarbonoxycarbonyl, or a nitrile group.
Each of the groups R, R.sup.1 and R.sup.2 and R.sup.3 independently may contain up to 25 carbon atoms but preferably contain up to 20 carbon atoms and especially not more than 10 carbon atoms. Each of the groups R, R.sup.1, R.sup.2 and R.sup.3 independently is preferably alkyl, cycloalkyl, aryl, aralkyl or alkaryl, especially containing up to 10 carbon atoms. If any of the groups R, R.sup.1 or R.sup.2 is substituted, the substituent or each substituent may be as previously described herein or, alternatively, the substituent may be a heteroatom in a heterocyclic group, which may itself be substituted with substituents as hereinbefore described. Heterocyclic groups include pyridyl, thienyl, imidazolyl, and thiazolyl. If any one of the groups R, R.sup.1, R.sup.2 R.sup.3 and is an alkyl group, this is preferably C.sub.1-6 -alkyl and more preferably C.sub.1-5 -alkyl. If any of the groups R, R.s

REFERENCES:
patent: 3931032 (1976-06-01), Karsten

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