Process for preparing 2- pyrimidinecarboxylates

Details Process for preparing 2- pyrimidinecarboxylates Process for preparing 2- pyrimidinecarboxylates

1997-07-14

1999-02-09

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D23952, C07D23932, C07D23928

Patent

active

058696679

ABSTRACT:
A process for preparing 2-pyrimidinecarboxylates of the general formula: ##STR1## wherein R is C.sub.1-6 -alkyl, C.sub.3-6 -cycloalkyl, aryl or arylalkyl, and R.sup.1 to R.sup.3 are, independently of one another, hydrogen, C.sub.1-6 -alkyl, fluorinated C.sub.1-6 -alkyl, C.sub.1-6 -alkoxy, (C.sub.1-6 -alkoxy)-C.sub.1-6 -alkyl or (C.sub.1-6 -alkoxy)carbonyl. These are obtained from the corresponding 2-halopyrimidine, the corresponding alcohol ROH and carbon monoxide in the presence of a palladium/phosphine complex and a base. 2-pyrimidinecarboxylates are intermediates for preparing herbicides.

REFERENCES:
Neunhoffer, H., and G. Werner, Liebigs Ann. Chem., (1974), 1190-1194.
Chemical Abstact, vol. 125, No. 3, (Jul. 15, 1996), 125:33323k.
Eilingsfeld, H. et al., Chem. Ber., (1968), 101, 2426-2434.
Neunhoeffer, H., and G. Werner, Liebigs Ann. Chem., (1974), 1190-1194.
Eilingsfeld, H., et al., Chem. Ber., (1968), 101, 2426-2434.

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