Human osteoclast-specific and -related genes

Details Human osteoclast-specific and -related genes Human osteoclast-specific and -related genes

1995-02-23

1996-09-03

Jones, W. Gary

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 691, 4351723, 4352523, 4353201, 536 231, C07H 2104, C12N 510, C12N 1570, C12Q 168

Patent

active

055522815

ABSTRACT:
The present invention relates to purified DNA sequences encoding all or a portion of an osteoclast-specific or -related gene products and a method for identifying such sequences. The invention also relates to antibodies directed against an osteoclast-specific or -related gene product. Also claimed are DNA constructs capable of replicating DNA encoding all or a portion of an osteoclast-specific or -related gene product, and DNA constructs capable of directing expression in a host cell of an osteoclast-specific or -related gene product.

REFERENCES:
Blair, Harry C., et al., "Extracellular-matrix degradation at acid pH. Avian osteoclast acid collagenase isolation and characterization", Biochemical Journal 290(3):873-884 (15 Mar. 1993).
Tezuka, Ken-Ichi, et al., "Identification of osteopontin in isolated rabbit osteoclasts", Biochemical and Biophysical Research Communications 186(2):914-916 (31 Jul. 1992).
Tezuka, Ken-Ichi, et al., "Molecular cloning of a possible cysteine proteinase predominantly expressed in osteoclasts", Journal of Biological Chemistry 269(2):1106-1108, (14 Jan. 1994).
Horton, Michael A. et al., "Monoclonal Antibodies to Osteoclastomas (Giant Cell Bone Tumors): Definition of Osteoclast-specific Cellular Antigens," Cancer Research 45, 5663-5669 (Nov. 1985).
Davies, John et al., "The Osteoclast Functional Antigen, Implicated in the Regulation of Bone Resorption, Is Biochemically Related to the Vitronectin Receptor," The Journal of Cell Biology 109, 1817-1826 (Oct. 1989).
Hayman, Alison, R. et al., "Purification and characterization of a tartrate-resistant acid phosphatase from human osteoclastomas," Biochem. J. 261, 601-609 (1989).
Sandberg, M. et al., "Localization of the Expression of Types I, III, and IV Collagen, TGF-.beta.1 and c-fos Genes in Developing Human Calvarial Bones," Developmental Biology 130, 324-334 (1988).
Sandberg, M. et al., "Enhanced expression of TGF-.beta. and c-fos mRNAs in the growth plates of developing human long bones," Development 102, 461-470 (1988).
Ek-Rylander, Barbro et al., "Cloning, Sequence, and Developmental Expression of a Type 5, Tartrate-resistant, Acid Phoshatase of Rat Bone," The Journal of Biological Chemistry 266(36), 24684-24689 (Dec. 25, 1991).
GenBank/EMBL Sequence Search Printout, pp. 1-19 (Jun. 24, 1993).

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