Piperazino derivatives as neurokinin antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514212, 540598, 544360, 544364, 544362, 544365, 544367, 544373, A61K 31495, C07D40112, C07D40312

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active

058694889

ABSTRACT:
The invention relates to compounds of the formula ##STR1## wherein Z, R.sub.c, y, m, u, Ar.sub.2, n, X, R.sub.c', I and Ar.sub.2 are as described herein. These compounds are neurokinin antagonists. These compounds are useful in the treatment of chronic airway diseases such as asthma.

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