Gene transfer into the kidney

Details Gene transfer into the kidney Gene transfer into the kidney

1995-03-30

1999-02-09

Ketter, James

Chemistry: molecular biology and microbiology

Differentiated tissue or organ other than blood, per se, or...

4351723, 4353201, 514 44, 536 231, 424 932, A01N 102, C12N 1563, A61K 4800, C07H 2104

Patent

active

058692304

ABSTRACT:
This invention pertains to a method of infecting an organ or a tissue other than a liver with an effective amount of a vector carrying genetic material of interest. This invention features a method of infecting kidney cells by introducing into the vasculature of a kidney a vector carrying genetic material of interest and maintaining the vector in contact with the renal vasculature for a period of time sufficient to allow infection of kidney cells with an effective amount of the vector, and under conditions which protect the kidney from ischemic damage. This method allows for infection of a significant number of renal endothelial cells. The method of the invention can be used for both in vivo and ex vivo applications.

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