Process for the production of an improved form of form 1 ranitid

Details Process for the production of an improved form of form 1 ranitid Process for the production of an improved form of form 1 ranitid

1995-04-07

1997-09-23

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D30752

Patent

active

056706715

ABSTRACT:
Process for the production of an improved form of Form 1 Ranitidine Hydrochloride having improved filtration and drying characteristics, said process comprising in a substantially anhydrous hydroxylic solvent, comprising at least one alkanol solvent having 3-4 carbon atoms, adding anhydrous hydrogen chloride gas to Ranitidine free base wherein said substantially anhydrous hydroxylic solvent has the characteristics that it solubilizes the Ranitidine free base and hydrogen chloride gas, and subsequently recovering the improved form of Form 1 Ranitidine Hydrochloride.

REFERENCES:
patent: 4128658 (1978-12-01), Price et al.
patent: 4521431 (1985-06-01), Crookes
patent: 4672133 (1987-06-01), Crookes
patent: 5523423 (1996-06-01), Murthy et al.

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