Nucleic acid ligands

Details Nucleic acid ligands Nucleic acid ligands

1995-03-27

1997-09-23

Zitomer, Stephanie W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 435 921, 935 77, 935 78, C07H 2102, C07H 2104, C12Q 168, C12P 1934

Patent

active

056706375

ABSTRACT:
A new class of nucleic acid compounds, referred to as nucleic acid antibodies, have been shown to exist that have a specific binding affinity for three dimensional molecular targets. In a preferred embodiment the ligand components of the nucleic acid antibodies are identified by the method of the invention referred to as the Systematic Evolution of Ligands by EXponential enrichment (SELEX), wherein a candidate mixture of nucleic acids are iteratively enriched in high affinity nucleic acids and amplified for further partitioning.

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