Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1995-11-20
1997-09-23
Bernhardt, Emily
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
514269, 544243, 544319, A61K 31675, A61K 31505, C07D23922, C07F 96512
Patent
active
056704941
ABSTRACT:
Disclosed are compounds, compositions and methods for inhibiting interleukin-1.beta. (1L-.beta.) protease activity. The compounds, N-(pyrimidinyl)-aspartic acid .alpha.-substituted methyl ketones and aspartic acid aldehydes, have the formula (I) set out herein.
These compounds are inhibitors of 1.beta.-converting enzyme and as such are useful whenever such inhibition is desired. For example, they may be used as research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which IL-.beta. protease activity is implicated.
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Chaturvedula Prasad V.
Dolle Roland E.
Prouty Catherine P.
Schmidt Stanley J.
Balogh Imre
Bernhardt Emily
Davis William J.
Sanoft
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