Method for locating the position of electrophysiological activit

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36441313, G06F 1542

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active

053922107

ABSTRACT:
A method for locating the position of endogenous, in vivo activities in an examination volume of a subject, by identifying the location in the examination volume of current dipoles generating an equivalent magnetic and electrical field, includes the formation of a probability density function on the basis of a objective function for one dipole model. From the probability density function, the dipole location is then calculated on the basis of a standardized anticipated position value, making use of the method of least squares. In this type of calculation, the structure of the objective function in the entire region of interest is taken into consideration. This prevents, in the method of least squares, the erroneous identification of local minimums instead of a global minimum. Moreover, the probability density function and the statistical variance supply useful additional information for interpreting the results.

REFERENCES:
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"Localization of Biological Sources with Arrays of Superconducting Gradiometers," Carelli et al., J. Appl. Phys. 59(2), Jan. 15, 1986, pp. 645-650.
"Application of Weight Functions to the Magnetic Localization of an Object," Mori, IEEE Trans. on Mag., vol. 25, No. 3 (1989), pp. 2726-2731.
"SQUID Arrays for Simultaneous Magnetic Measurements: Calibration and Source Localization Performance," Ribeiro et al., IEEE Trans. on Biomed. Eng., vol. 35, No. 7 (1988) pp. 551-560.

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