Antipsychotic 1-fluorophenylbutyl-4-(2-pyrimidinyl)piperazine de

Details Antipsychotic 1-fluorophenylbutyl-4-(2-pyrimidinyl)piperazine de Antipsychotic 1-fluorophenylbutyl-4-(2-pyrimidinyl)piperazine de

1984-12-18

1986-08-12

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544238, 544295, 544319, 544374, A61K 31505, C07D40304, C07D40514

Patent

active

046056556

ABSTRACT:
Disubstituted N,N-piperazinyl derivatives are disclosed wherein one substituent is a pyrimidin-2-yl ring and the other is a 4 carbon chain attached to a p-fluorophenyl ring at the terminal carbon. The terminal carbon of this butylene chain is also bonded to an oxygen atom as part of a carbonyl, carbinol, or ketal functionality. These compounds possess psychotropic properties, particularly atypical antipsychotic activity of good duration. By virtue of pre-clinical pharmacological testing, these compounds appear useful as potential antipsychotic agents which lack the typical movement disorder side-effects of standard antipsychotic agents.

REFERENCES:
patent: 2973360 (1961-02-01), Janssen
patent: 2979508 (1961-04-01), Janssen
patent: 2985657 (1961-05-01), Janssen
patent: 3299067 (1967-01-01), Regnier et al.
patent: 3808210 (1974-04-01), Regnier et al.
patent: 4316899 (1982-02-01), Markwell
Burger's Medicinal Chemistry, 4th Edition, Part III, M. E. Wolff, Editor, John Wiley & Sons, New York (1981) pp. 917-928.
Chem. Abs., vol. 75, 49136m (1971) (German Offen. DE 2,053,179).
Janssen, "Chemical Abstracts", vol. 55, 1961, col. 5549c.

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