Use of L-arginine in the treatment of hypertension and other vas

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

A61K 31195

Patent

active

052179974

ABSTRACT:
A method for treating a high vascular resistance disorder in a mammal by administering to a mammalian organism in need of such treatment a sufficient amount of L-arginine or pharmaceutically acceptable salt thereof to treat a high vascular resistance disorder. The L-arginine is typically administered in the range of about 1 mg to 1500 mg per day. High vascular resistance disorders include hypertension, primary or secondary vasospasm, angina pectoris, cerebral ischemia and preeclampsia. Also disclosed is a method for preventing or treating bronchial asthma in a mammal by administering to a mammalian organism in need of such prevention or treatment a sufficient amount of L-arginine to prevent or treat bronchial asthma.

REFERENCES:
patent: 3542929 (1970-11-01), Roberts
Lais, et al., "Mechanism of Vascular Hyperresponsiveness in the Spontaneously Hypertensive Rat," Cir. Res., 36/37: Suppl. 1, I-216, to I-222 (1975).
Pinto, et al., "Arachidonic Acid-Induced Endothelial-Dependent Relaxations of Canine Coronary Arteries: Contribution of a Cytochrome P-450-Dependent Pathway," J. Pharmacol. Exp. Therap., vol. 240, No. 3, 856-863 (1987).
Luscher, et al., "Endothelium-Dependent Responses in Cartoid and Renal Arteries of Normotensive and Hypertensive Rats," Hypertension, vol. 11, No. 6, Part 2, 573-578 (1988).
Sacerdoti, et al., "Treatment with Tin Prevents the Development of Hypertension in Spontaneously Hypertensive Rats," Science, vol. 243, 388-390 (1989).
Martasek, et al., "Heme Arginate Lowers Blood Pressure in Spontaneous Hypertensive Rats," Clin. Res., vol. 37, 553A (1989).
Merrick, et al., "Alternations in Hepatic Microsomal Drug Metabolism and Cytochrome P450 Proteins in Spontaneously Hypertensive Rats," Pharmacol. 30, 129-135 (1985).
Sacerdoti, et al., "Renal Cytochrome P450-Dependent Metabolism of Arachidonic Acid in Spontaneously Hypertensive Rats," Biochem. Pharmacol., vol. 37, No. 3, 521-527 (1988).
Kappas, et al., "Control of Heme Metabolism with Synthetic Metalloprophyrins," J. Clin. Invest., vol. 77, 335-339 (1986).
Simionatto, et al., "Studies of the Mechanism of Sn-Protoporphyrin Suppression and Hyperbilirubinemia: Inhibition of Heme Oxidation and Bilirubin Production," J. Clin. Invest., vol. 75, 513-521 (1985).
Escalante, et al., "19(S)Hydroxyeicosatetraenoic Acid is a Potent Stimulator of Renal Na.sup.+ -K.sup.+ -ATPase," Biochem. & Biophys. Res. Commun., vol. 152, No. 3, 1269-1273 (1988).
Escalante, et al, "Vasoactivity of 20-Hydroxyeicosatetraenoic Acid is Dependent on Metabolism by Cyclooxygenase," J. Pharmacol. Exp. Therap., vol. 248, No. 1, 229-232 (1989).
Furchgott, et al., "The Role of Endothelium in the Responses of Vascular Smooth Muscle to Drugs," Ann. Rev. Pharmacol. Toxicol., 24, 175-197 (1984).
Palmer, et al., "Vascular Endothelial Cells Synthesize Nitric Oxide from L-Arginine," Nature, vol, 333, 664-666 (1988).
Ignarro, et al., "Endothelium-Derived Nitric Oxide: Actions and Properties," FASEB J., vol. 3, 31-36 (1989).
Kordac, et al., "Changes of Myocardial Functions in Acute Hepatic Porphyrias, Role of Heme Arginate Administration," Ann. Med., 21, 273-276 (1989).
Rees, et al., "Role of Endothelium-derived Nitric Oxide in the Regulation of Blood Pressure," Proc. Natl. Acad. Sci. USA, vol. 86, 3375-3378 (1989).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Use of L-arginine in the treatment of hypertension and other vas does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Use of L-arginine in the treatment of hypertension and other vas, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of L-arginine in the treatment of hypertension and other vas will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1934371

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.