Indolyl indolylakyl-N-terminal cycloalkoxy-C-terminal amino hydr

Details Indolyl indolylakyl-N-terminal cycloalkoxy-C-terminal amino hydr Indolyl indolylakyl-N-terminal cycloalkoxy-C-terminal amino hydr

1992-07-16

1993-06-08

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514414, 548467, 548492, 548495, A61K 31405, C07D20912, C07D20914

Patent

active

052179885

ABSTRACT:
Non-peptidyl compounds characterized generally as indolyl/indolylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy .beta.-amino acid derivatives are useful as renin inhibitors for treatment of hypertension. Compounds of particular interest are of the formula ##STR1## wherein R.sub.1 is selected from ##STR2## wherein X is selected from ##STR3## wherein each of Y and Z is independently selected from hydrido, chloro, fluoro, methoxy and dimethylamino; wherein n is a number selected from zero through four, inclusive; wherein each of R.sub.2 and R.sub.4 is independently selected from hydrido and methyl; wherein R.sub.3 is methyl or ethyl; wherein R.sub.5 is cyclohexylmethyl; wherein R.sub.6 and R.sub.7 are taken together to form a partially saturated or fully saturated heterocyclic ring containing five to eight ring members with one or two ring members being oxygen atoms and the remaining ring members being carbon atoms, and which heterocyclic ring may be optionally substituted with lower alkyl; or a pharmaceutically-acceptable salt thereof.

REFERENCES:
patent: 5145845 (1992-09-01), Johnson et al.
Umezawa et al., J. Antibiot. (Tokyo), 23, 259-262 (1970).
Gross et al., Science, 175, 656 (1971).
Boger et al., Nature, 303, 81-84 (1983).
Kokubu et al., Biochem. Biophys. Res. Commun., 118, 929-933 (1984).
Castro et al., FEBS Lett., 167, 273 (1984).
Hanson et al., Biochem. Biophys. Res. Commun., 132, 155-161 (1985) and 146, 959-963 (1987).

Affiliated with

Also associated with

Rating

Indolyl indolylakyl-N-terminal cycloalkoxy-C-terminal amino hydr does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Indolyl indolylakyl-N-terminal cycloalkoxy-C-terminal amino hydr, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Indolyl indolylakyl-N-terminal cycloalkoxy-C-terminal amino hydr will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1934307