Novel enzyme inhibitors

Details Novel enzyme inhibitors Novel enzyme inhibitors

1980-06-16

1981-07-07

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603262, 2603264, 26032647, 26032648, 560 24, 560 32, 560159, 560169, 564136, 564152, 564153, 564159, C07C10352, C07D20724

Patent

active

042773954

ABSTRACT:
Compounds of the following general formula are irreversible inhibitors of pancreatic elastase: ##STR1## wherein M is hydroxy, lower alkoxy, benzyloxy or --NY.sub.1 Y.sub.2 wherein each of R.sub.4 and R.sub.5 is hydrogen or lower alkyl; R is CF.sub.3, CHF.sub.2 or CH.sub.2 F; R.sub.1 is straight or branched lower alkyl; R.sub.2 is defined the same as R.sub.1 or is benzyl; R.sub.30 is CHO, carbobenzoxy, tert-butoxycarbonyl, benzoyl or lower alkanoyl; X is pro, ala or leu and Y and Z together form a single bond; or Y-X is ala-pro, ala-ala or ala-leu and Z forms a single bond; and Z-Y-X is ala-ala-pro, ala-ala-ala or pro-ala-leu.

REFERENCES:
patent: 4176116 (1979-11-01), Hassall et al.

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