Method of diagnosing blood clots using fibrin-binding proteins

Details Method of diagnosing blood clots using fibrin-binding proteins Method of diagnosing blood clots using fibrin-binding proteins

1988-09-22

1993-06-08

Stoll, Robert L.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

530402, 530409, 530410, 530380, 930280, 424 9, A61K 4902, A61K 4300

Patent

active

052177050

ABSTRACT:
A fibrin-binding protein such as t-PA is labeled with a detectable substance, such as a radionuclide, and administered to a patient for diagnosis of blood clots and for monitoring the dissolution thereof during therapy. The detectable substance preferably is attached to t-PA through linkers which specifically bind to the portion of the t-PA protein responsible for enzymatic activity, thereby diminishing this activity while leaving the fibrin-binding property of the protein intact.

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