Compositions – Preservative agents – Anti-corrosion
Patent
1991-10-11
1993-06-08
Lovering, Richard D.
Compositions
Preservative agents
Anti-corrosion
252312, 514 6, 514832, 514833, 514938, 514939, 514941, A61K 9113, A61K 3714, B01J 1300
Patent
active
052176487
ABSTRACT:
A process is provided wherein hemoglobin, a fragile material, is formulated into high hemoglobin content water-in-oil-in-water multiple emulsion while maintaining high yields and high oxygen exchange activity. A multiple emulsion of aqueous oxygen carrying material in oil in outer aqueous phase is suitable for provision of oxygen for oxygen transfer processes. A hemoglobin multiple emulsion in physiologically compatible oil in an outer aqueous saline solution is provided in sufficiently small droplet size to provide oxygen flow through blood vessels to desired body tissues or organs thereby providing a blood substitute.
REFERENCES:
patent: 3823901 (1974-07-01), Samejima et al.
patent: 3993581 (1976-11-01), Yokoyama et al.
patent: 4146499 (1979-03-01), Rosano
patent: 4461717 (1984-07-01), Moore
patent: 4533254 (1985-08-01), Cook et al.
patent: 4569784 (1986-02-01), Moore
patent: 4590086 (1986-05-01), Takahashi et al.
patent: 4612370 (1986-09-01), Hunt
patent: 4714566 (1987-12-01), Takahashi et al.
patent: 4776991 (1988-10-01), Farmer et al.
patent: 4804495 (1989-02-01), Bouchez et al.
patent: 4808334 (1989-02-01), Ezaki et al.
patent: 4866096 (1989-09-01), Schweighardt
patent: 5061688 (1991-10-01), Bessinger et al.
Sehgal, L. R., Gould, S. A., Rosen, A. L., Moss, G. S.: Appraisal of Red Cell Substitutes: Hemoglobin Solution and Perfluorochemical Emulsions, Laboratory Medicine, 14:545, 1983.
Gould, S. A., Rosen, A. L., Sehgal, L. R., Moss, G. S.: Red Cell Substitutes: Hemoglobin Solution or Fluorocarbon?, J. Trauma, 22:736, 1982.
Gould, S. A., Rosen, A. L., Sehgal, L. R., Moss, G. S.: Hemoglobin Solutions as Red Cell Substitutes, Trans. Am. Soc. Art. Int. Organs, 26:350, 1980.
Sehgal, L. R. , Rosen, A. L., Gould, S. A., Moss, G. S.: Polymerized Pyridoxylated Hemoglobin: A Red Cell Substitute with Normal Oxygen Capacity, Surgery, 95:433, 1984.
Miller, I., "Synthetic Blood Substitutes: Where Are We and Where do We Go From Here?", CRC, Crit. Rev. BioEng., 149-178, Dec. 1978.
T. Davis, W. Asher and H. Wallace, Artificial Red Cells with Crosslinked Hemoglobin Membranes, Applied Biochemistry and Biotechnology, vol. 10, 1984.
S. Matsumoto, Y. Kita and D. Yonezawa, An Attempt at Preparing Water-in-Oil-in-Water Multiple-Phase Emulsions, Journal of Colloid and Interface Science, vol. 57, No. 2, Nov. 1976.
S. Matsumoto, Y. Ueda, Y. Kita and D. Yonezawa, Preparation of Water-in-Olive Oil-in-Water Multiple-Phase Emulsions in an Eatable Form, Agric. Biol. Chem., 42 (4), 739-743, 1978.
P. E. Keipert and T. M. S. Chang, In Vivo Assessment of Pyridoxylated Crosslinked Polyhemoglobin as an Artificial Red Cell Substituted in Rats. vol. 29, pp. 329-333, Trans. Am. Soc. Artif. Intern. Organs, 1985.
P. E. Keipert and T. M. S. Chang, Pyridoxylated Polyhemoglobin as a Red Cell Substitute for Resuscitation of Lethal Hemorrhagic Shock in Conscious Rats, vol. 13(1 & 2), pp. 1-15, Biomat. Med. Dev. Art. Org., 1985.
C. M. Borwanker, S. B. Pfeiffer, S. Zheng, R. L. Bessinger, and D. T. Wasan, Formulation and Characterizaton of a Multiple Emulsion for Use as a Red Blood Cell Substitute, Biotechnology Progress, vol. 4, No. 4, 210-217, Dec., 1988.
S. Zheng, R. L. Beissinger, and D. T. Wasan, The Stabilization of Hemoglobin Multiple Emulsion for Use as a Red Blood Cell Substitute, Journal of Colloid and Interface Science, vol. 144, No. 1, 72-85, Jun. 1991.
Szoka, Jr. et al.: "Procedure for Preparation of Liposomes with Large Internal Aqueous Space and High Capture by Reverse Phase Evaporation", Proc. Natl. Acad. Sci. U.S.A., vol. 75, No. 9, pp. 4194-4198, Sep. 1978 Biochemistry.
Hackh's Chemical Dictionary, Fourth Edition, Revised and Edited by Julius Grant, McGraw-Hill Book Co., New York 1969, pp. 240, 168 and 169.
International Journal of Pharmaceutics, vol. 11, 1982, pp. 277-308, "The Formulations and Stability of Multiple Emulsions".
Beissinger Richard L.
Rosen Arthur L.
Sehgal Lakshman R.
Wasan Darsh T.
Illinois Institute of Technology
Lovering Richard D.
Northfield Laboratories, Inc.
LandOfFree
Process for preparation of hemoglobin multiple emulsions does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for preparation of hemoglobin multiple emulsions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparation of hemoglobin multiple emulsions will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1931815