Oligonucleotide conjugates

Details Oligonucleotide conjugates Oligonucleotide conjugates

1993-02-16

1995-02-21

Yarbrough, Amelia Burgess

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

530402, C07H 1512

Patent

active

053917235

ABSTRACT:
There is disclosed an oligonucleotide strand or duplex-targeting protein conjugate, a linking group to link an oligonucleotide to a targeting protein, and a method for producing targeting protein conjugates containing oligonucleotide strands or duplexes. A suitable linker is a bifunctional phosphoramidite ester that binds to both the targeting protein and the oligonucleotide strand or duplex. The invention can be used for delivering chemotherapeutic agents to target sites based upon the specificity of the targeting protein and to deliver specific oligonucleotide sequences to a target site to hybridize and inhibit the expression of complementary sequences within the target cell genome.

REFERENCES:
Cheng et al. (1983) Nucl. Acids Res. vol. 11, No. 3, 659-664.
Chu et al. (1983) Nucl. Acids Res. vol. 11, No. 18, pp. 6513-6524.
Caruthers, M. H. Chapter 3, "DNA Synthesis for Nonchemists: The Phosphoramidit Method on Silica Supports", In Synthesis and Applications of DNA and RNA (S. Narang, ed.) Academic Press, New York, pp. 47-94 (1987).
Chu et al., Nucl. Acids Res. 11(18): 6513-6529, 1983.
Cheng et al., Nucl. Acids Res. 11(3): 659-669, 1983.

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