Polyfluorinated tripeptide thrombin inhibitors

Details Polyfluorinated tripeptide thrombin inhibitors Polyfluorinated tripeptide thrombin inhibitors

1994-02-18

1995-02-21

Higel, Floyd D.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Tripeptides, e.g., tripeptide thyroliberin , etc.

546146, 546145, 546155, 548468, 548532, 548538, A61K 3702, A61K 3764, C07K 508

Patent

active

053917057

ABSTRACT:
This invention relates to novel polyfluorinated alkyl derivatives of certain tripeptides, to the methods for their preparation, the intermediates therefore, to their use in inhibiting thrombin and lung tryptase and in their end-use application as anti-coagulants useful in treating thrombophlebitis and coronary thrombosis and in the treatment of asthma.

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