Process for the preparation of 3-unsubstituted indoles using met

Details Process for the preparation of 3-unsubstituted indoles using met Process for the preparation of 3-unsubstituted indoles using met

1991-01-18

1992-10-20

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546178, 548502, C07D20910, C07D40312

Patent

active

051571226

ABSTRACT:
An indole having the formula I: ##STR1## is prepared by a Fischer-Indole reaction employing a mixture of phosphorous pentoxide and methane sulfonic acid as an acid catalyst. The reaction, which is optionally run in a co-solvent, provides 3-unsubstituted indoles in high yields with high regioselectivity. The indole thus prepared is an intermediate in the synthesis of leukotriene biosynthesis inhibitors.

REFERENCES:
P. E. Eaton et al., Phosphorous Pentoxide-Methanesulfonic Acid, J. Org. Chem. 38, 4071 (1973).
A. Guy and J. P. Guette, Utilization of Polyphosphoric Acid Synthesis, 1980, 222.
H. Illy and L. Funderburk, Fisher Indole Syn. Direction of Cyclization, J. Org. Chem., 33, 4283 (1968).
M. H. Palmer and P. S. McIntyre, Fischer Indole Syn. Unsymmetrical Ketones, J. Chem. Soc. (B), 1969, 446.

Affiliated with

Also associated with

Rating

Process for the preparation of 3-unsubstituted indoles using met does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of 3-unsubstituted indoles using met, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of 3-unsubstituted indoles using met will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-193027