Trichothecene conjugates

Details Trichothecene conjugates Trichothecene conjugates

1988-05-16

1992-10-20

Cashion, Jr., Merrell C.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Secretin or gastrin; related peptides

530327, 530345, C07K 730

Patent

active

051571048

ABSTRACT:
Conjugates of trichothecenes and agents that bind to a defined population of cells are disclosed. Preferred are conjugates of trichothecene molecules with polyclonal or monoclonal antibodies or fragments thereof that recognize antigens that are present only on tumor cells or are augmented in their expression on tumor cells as compared to normal tissues. Trichothecene molecules are coupled to the agent through non-covalent and covalent linkages, such as peptide bonds, disulfide bonds, thioester bonds, or thioether bonds. A method for inhibiting the growth and metabolism of antigen-positive cells is also disclosed.

REFERENCES:
patent: 4507234 (1985-03-01), Kato et al.
patent: 4618585 (1986-10-01), Chan
patent: 4624846 (1986-11-01), Goldenberg
patent: 4744981 (1988-05-01), Pavanasasivam
patent: 4906452 (1990-03-01), Siram
patent: 5066789 (1991-11-01), Srinivasan et al.
Olsnes et al., Pharmac. Ther., vol. 15, pp. 355-379 (1982).
Mulshine et al., Ann. New York, Acad. Sci., vol. 547, Dec. 30, pp. 361-372 (1988).
Polak et al., Ann. New York, Acad. Sci., vol. 547, Dec. 30, pp. 321-335 (1988).
Chu et al., Appl. Environ. Microbiol., vol. 48(4), pp. 781-784 (1984).
Weber et al., J. Clin. Invest., vol. 75, pp. 306-309 (1985).
Lehninger, Biochemistry, 2nd Ed., (Worth Publishers, New York), pp. 73-75 (1978).
Doslands Illustrated Medical Dictionary, 25th Ed., (W. B. Saunders, Philadelphia) p. 680.
Roitt, Essential Immunology, 5th Ed., (Blackwell Scientific Publications, Oxford), pp. 6-7.
F. S. Chu et al., Chem. Abstra. 101:228260z (1984).
K. W. Hunter, Jr. et al., Chem. Abstr. 102:76957n (1985).
J. R. Bamburg, Prog. Molec. Subcell. Biol. 8:41-110 (1983).
J. W. Uhr, J. Immunol. 133:i-x (1984).
B. M. J. Foxwell, Immunotoxicology, Academic Press, London, (1983), pp. 359-368, Protection Against Trichothecene Mycotoxins, National Academy Press, Washington, D.C., (1983), pp. 17-20; 129-136.
Murphy et al., Cancer Treatment Rep., 62, (1978), pp. 1497-1502.
Adler et al., Cancer Treatment Rep., 68 (1984), pp. 423-425.
Heikkila et al., J. Biol. Chem., vol. 262, 34, Dec. 5, 1987, pp. 16456-16460.
Kris et al., J. Biol. Chem., vol. 262, 23, Aug. 15, 1987, pp. 11215-11220.
Carney et al., Cancer Research, 47, Feb. 1, 1987, pp. 821-825.
Sausville et al., J. Biol. Chem., vol. 261, 5, Feb. 15, 1986, pp. 2451-2457.
Gargosky et al., Biochem J. (1987), vol. 247, pp. 427-432 (printed in Great Britain).
A. Huntley Blair and Tarun I. Ghose, J. Immunol. Meth. (1983) vol. 59, pp. 129-143.

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