Microbial reduction of benzazepines and benzothiazepine derivati

Details Microbial reduction of benzazepines and benzothiazepine derivati Microbial reduction of benzazepines and benzothiazepine derivati

1990-11-19

1996-09-24

Wityshyn, Michael G.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

435118, 435121, 435122, 435280, 435822, 435911, C12P 1714, C12P 1710, C12P 1716

Patent

active

055590179

ABSTRACT:
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A novel process comprises reducing a benzazepine or benzothiazepine at the 3-position in d-cis configuration by treatment with reductase-supplying microorganisms or enzymes derived therefrom. The process can be catalyzed in a single stage by growing microbial cultures or in a two-stage fermentation/transformation by resting cell-suspensions. The enzymes derived from the microorganisms can be used in free state or immobilized form. The microorganisms and enzymes catalyzes the specific reduction with 90 to 99% conversion efficiency to 99% or greater optical purity of the desired enantiomer.

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