Subcutaneous implantable multiple-agent delivery system

Details Subcutaneous implantable multiple-agent delivery system Subcutaneous implantable multiple-agent delivery system

Filed on

1993-03-01

Date issued

1995-02-21

Examiner

Green, Randall L.

Patent Class

Surgery

SubClass

Controlled release therapeutic device or system

SubSubClass

Implanted dynamic device or system

Other Related Categories

424424, 424425, A61K 922

Type

Patent

Status

active

Patent number

053911644

Description

ABSTRACT:
An implantable multiple-agent biologic delivery system includes a pod proportioned for subcutaneous implantation beneath the dermis of the skin, the pod including a porous surface and having at least one internal chamber which is in fluid communication with the porous surface. The system includes a dome proportioned for selectable detachable securement to the chamber of the pod. The dome includes interior chambers, each in fluid communication with the interior of the pod. Bio-acting agents, such as hormones, enzymes, biologic response modifiers, free radical scavengers, and genetically altered cell cultures, may be provided, within the chambers of the dome, prior to implantation. Such agents within the dome will, through the use of time release micropumps, enter the interior of the pod for transmission through the porous surfaces into a vascular growth factor stimulated capillary matrix and then to the bloodstream of the user. The pod may be removed, refilled, and resecured to the dome upon exhaustion of its contents or upon medical requirement for changes in medication, or may be percutaneously refilled in situ thru injection into the dome.

REFERENCES:
patent: 4944659 (1990-07-01), Labbe et al.
patent: 5030216 (1991-07-01), Theeuwes et al.
patent: 5045060 (1991-09-01), Melsky et al.
patent: 5201728 (1993-04-01), Giampapa

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