Process for preparing penems

Details Process for preparing penems Process for preparing penems

1988-05-12

1990-01-30

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D49900, A61K 3143

Patent

active

048974765

ABSTRACT:
During the preparation of 6-(substituted methylene)-2-penem compounds (which are known for their anti-bacterial and .beta.-lactamase inhibitory properties) mixtures of the E-isomer and the Z-isomer may be formed. The Z-isomer is, however generally preferred, and the present invention provides a process whereby the E-isomer may be converted into the Z-isomer by reaction with an aromatic heterocyclic thiol in the presence of a base.

REFERENCES:
patent: 4438036 (1984-03-01), Corbett et al.
patent: 4774238 (1988-09-01), Broom et al.
Tetra Hedron, vol. 39, pp. 78-82, (1983).

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