Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1990-12-07
1991-09-17
Dentz, Bernard
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546118, 435119, C07D47104, A61K 31435, C12P 1712
Patent
active
050495658
ABSTRACT:
Fermentation of the microorganism Streptomyces sp. (MA6750) ATTC No. 55042 in the presence of the Angiotensin II (A II) receptor antagonist ##STR1## yields three analogs, each having a shikimate sugar-like moiety attached to the tetrazole, which are also A II antagonists useful in the treatment of hypertension and congestive heart failure and other indications known to respond to A II antagonists.
Arison Byron H.
Chen Shieh-Shung T.
White Raymond F.
Dentz Bernard
DiPrima Joseph F.
Merck & Co. , Inc.
Nicholson William H.
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