Preparation of thiazolidine derivatives

Details Preparation of thiazolidine derivatives Preparation of thiazolidine derivatives

1981-12-11

1986-04-22

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

548146, C07D27704

Patent

active

045844070

ABSTRACT:
A method of preparing a thiazolidine derivative of the formula ##STR1## where R, R.sub.1, R.sub.2 R.sub.3 and R.sub.4 are each independently hydrogen or appropriate aromatic or aliphatic substituents, comprises reacting together a sulphur donor, such as sulphur or hydrogen sulphide, an aldehyde of the formula RCHO, such as benzaldehyde or formaldehyde, and an ethanolamine derivative of the formula, or including the radical, NH.sub.2 CR.sub.1 R.sub.2 CR.sub.3 R.sub.4 X, where X is a leaving group. A suitable derivative may be, for instance, aminoethylsulphate (AES). The thiazolidine derivative may be used, for example, as intermediates in the preparation of other compounds such as cysteamine.

REFERENCES:
patent: 4011233 (1977-03-01), Dobs
Sandler et al, Org. Functional Group Prep. pp. 480-481 (1968).

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