Novel Fredericamycin A derivatives

Details Novel Fredericamycin A derivatives Novel Fredericamycin A derivatives

1984-08-09

1986-04-22

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D22118

Patent

active

045843775

ABSTRACT:
Disclosed herein are Fredericamycin A derivatives, each, represented by the following general formula (I): ##STR1## wherein R means a hydrogen atom or acyl group, A denotes ##STR2## and dotted bonds are optional, with a proviso that when A is ##STR3## or the dotted bonds are contained, R is other than hydrogen atom. They have excellent antibacterial and antitumor activities and at the same time, are extremely stable compared with Fredericamycin A.

REFERENCES:
Misra et al., "J. Am. Chem. Soc." (1982), vol. 104, pp. 4478-4479.
Pandey et al., J. Antibiotics vol. 34, pp. 1389-1401, (1981).
Warnick-Pickle et al., J. Antibiotics vol. 34, pp. 1402-1407, (1981).

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