Pyrimidinecarboxylic acid derivatives

Details Pyrimidinecarboxylic acid derivatives Pyrimidinecarboxylic acid derivatives

1987-04-08

1988-06-28

Ford, John M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514212, 5142278, 5142328, 5142358, 544295, 544316, 544318, 544122, 544 60, 544 585, 544 584, 540601, A61K 31505, C07D23922, C07D40106, C07D41706

Patent

active

047539461

ABSTRACT:
Pyridine compounds of the formula ##STR1## wherein R.sub.4 is aryl or heterocyclo are disclosed. These compounds are useful as cardiovascular agents due to their calcium entry blocking vasodilator activity.

REFERENCES:
patent: 4048171 (1977-09-01), Bossert et al.
patent: 4572908 (1986-02-01), Campbell et al.
Khanina et al., "Synthesis and Pharmacological Investigation of Some Derivatives of 1,2,3,4-Tetrahydropyrimidine-5-Carboxylic Acid", Khim. Farm. Zh., vol. 12, pp. 1321-1323 (1978).
Konyukhov et al., "Synthesis and Investigation of Heterocyclo Derivatives with Biological Activity", Zh. Organ. Khim., vol. 1, No. 8, pp. 1487-1489 (1965).

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