Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1998-04-30
2000-05-30
Wilson, James O.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 62, 514 67, 514946, 514965, 536 551, 536 552, A61K 31715
Patent
active
060691379
DESCRIPTION:
BRIEF SUMMARY
FIELD OF THE INVENTION
This invention relates to treatment of traveller's diarrhea, including diarrhea caused by enterotoxigenic Escherichia coli (ETEC). More specifically, the invention concerns neutralization and removal of E. coli heat-labile toxin (LT) associated with ETEC. This invention also relates to prevention of ETEC, the causative agent of traveller's diarrhea from colonizing the intestinal tract.
REFERENCES
The following references are cited in the application as numbers in brackets ([ ]) at the relevant portion of the application. subunit/whole-cell cholera vaccine Lancet: 338, 1285-1289 (1991). and treatment. Clin. Infect. Dis: 16, 616-626 (1993). Related Escherichia coli Heat-Labile Enterotoxin" Microbiological Reviews, 56, No. 4:622-647 (1992). developing countries--a multicenter study in five countries., J. Clin. Microbiol. 31: 851-856 (1993). coli isolated from U.S. troops deployed to the middle east., J. Clin. Microbiol. 31: 851-856 (1993). military personnel deployed to South America and West Africa, Am. J. Trop. Med. Hyg. 48: 243-248 (1993). coli Binds to Polyactosaminoglycan-Containing Receptors in CaCo-2 Human Intestinal Epithelial Cells", Biochemistry, 33:12886-12895 (1994). Enterotoxins", Advances in Lipid Research, 25:165-187 (1993). in enterotoxigenic Escherichia coli attachment is a sialoglycoconjugate J Clin. Microb. 21: 951-954 (1985). for Escherichia coli colonization factor antigens., FEMS Microb. Lett. 72: 289-292 (1990). enterotoxigenic Escherichia coli to rabbit intestinal glycoproteins is competitively prevented by GalNAc(1-4)Gal containing glycoconjugates., Infect. Immun. 63: 640-646 (1995). enterotoxin of Escherichia coli to GM1, derivatives of GM1 and nonlipid oligosaccharide polyvalent ligands J. Biol. Chem. 264:13233-13237 (1989). cholera toxin and Escherichia coli heat-labile enterotoxins LTh-I, LTh-IIa, and LTh-IIb Infect. Immun. 56: 1748-1753(1988). glycosylated proteins with lactose by aminocarbonyl reaction, Microbiol. Immunol. 38:273-279 (1994). coli., Nature 355:561-564(1992). heat-labile enterotoxin (LT) and cholera toxin (CT), Mol. Microbiol. 13:745-753 (1994). heat-labile enterotoxin and cholera toxin using immobilized galactose Microb. Path. 16: 71-76 (1994). related to the blood-group Lewis A", J. Am. Chem. Soc., 97:4076-83 (1975). No. 4,137,401, issued Jan. 30, 1979. 2-Amino-2-Deoxyglycosides from glycals", U.S. Pat. No. 4,362,720, issued Dec. 7, 1982. 4-0-.alpha.-D-Galactopyranosyl-D-Galacto-Pyranose", Carbohy. Res., 62: 245-252 (1978). glycosides of the trisaccharide portion [.alpha.-D-Gal-(1-4)-.beta.-D-Gal(1-4)-.beta.-D-Glc] of the blood group p.sup.k antigen: preparation of neoglycoproteins", Carbohydrate Research, 127: 15-25 (1984). O-.alpha.-D-Galactopyranosyl-(1-3)-0-.beta.-D-Galactopyranosyl-(1-4)-2-Ace tamido-2-Deoxy-.beta.-D-Glucopyranoside", Carbohy. Res., 136: 207-213 (1985). methyl 4-0-.alpha.-D-galactopyranosyl-.beta.-D-galactopyranoside for studies of inhibition of pyelonephritogenic fimbriated E. coli adhesion to urinary epithelium-cell surfaces", Carbohy. Res., 137: 270-275 (1985). 11. Synthesis of the Trisaccharide O-.alpha.-D-Galactopyranosyl-(1-3)-0-.beta.-D-galactopyranosyl-(1-4 4)-2-acetamido-2-deoxy-D-glucopyranose", J. C. S. Perkin, I: 326-330 (1981). and Isoglobotriaosyl-E-Ceramide," Carbohydr. Res., 163: 189-208 (1987). of the Gal-.alpha.-(1-3)-Gal-.beta.-(1-4)-GlCNAc Epitope. A specific Determinant for Metastatic Progression?," Liebigs Ann. Chem., 607-614 (1991). Immunoadsorbents, and Methods for Their Preparation", U.S. Pat. No. 5,079,353, issued Jan. 7, 1992. 5835-5857 (1990). of Sialyl-Lewis' Antigenic Determinant", Sialic Acids, Proc. Japan-German Symp. Berlin 22-23 (1988). Oligosaccharides", Angew. Chem. Int. Ed. Eng., 21:155-173 (1982). Oligosaccharides--Are There Alternatives to the Koenigs-Knorr Method?" Angew. Chem. Int. Ed. Eng., 25:212-235 (1986). Oligosaccharide Synthesis", Glycoconjugate J., 4:97-108 (1987). Res., 209: c1-c4 (1991). Preparation of Immunogens bearing Immunodeterminants Known to Occur on Glycop
REFERENCES:
patent: 4137401 (1979-01-01), Lemieux et al.
patent: 4238473 (1980-12-01), Lemieux et al.
patent: 4362720 (1982-12-01), Lemieux et al.
patent: 5079353 (1992-01-01), Ratcliffe et al.
patent: 5627163 (1997-05-01), Heerze et al.
patent: 5637576 (1997-06-01), Heerze et al.
Abbas, S.A. et al., "Tumor-Associated Oligosaccharides I: Synthesis of Sialyl-Lewis.sup.2 Antigenic Determinant" Sialic Acids, Proc. Japan-German Symp. Berlin, pp. 22-23 (1988).
Amin, T. et al., "A new method for the purification of the B subunit (EtxB) of Escherichia coli heat-labile exterotoxin" Biochemical Society Transactions 21: 213S (1993).
Amvam-Zollo, P. et al., "Streptococcus pneumoniae Type XIV Polysaccharide: Synthesis of a Repeating Branched Tetrasaccharide with Dioxa-Type Spacer-Arms" Carbohydrate Research 150: 199-212 (1986).
Armstrong, G.D. et al., "Investigation of shiga-like toxin binding to chemically synthesized oligosaccharide sequences" J. Infect. Dis. 164: 1160-7 (1991).
Bartus, H. et al., "Indications that the erythrocyte receptor involved in enterotoxigenic Escherichia coli attachment is a sialoglycoconjugate" J. Clin. Microb. 21: 951-954 (1985).
Bourgeois, A.L. et al., "Etiology of acute diarrhea among United States military personnel deployed to South America and West Africa" Am. J. Trop. Med. Hyg. 48: 243-248 (1993).
Chernyak, A.Y. et al., "A New Type of Carbohydrate-Containing Synthetic Antigen: Synthesis of Carbohydrate-Containing Polyacrylamide Copolymers having the Specificity of 0:3 and 0:4 Factors of Salmonella" Carbohydrate Research, 128: 269-282 (1984).
Cox, D., et al. "A New Synthesis of 4-0-.alpha.-D-Galactopyranosyl-D-Galacto-Pyranose" Carbohy. Res. 62: 245-252 (1978).
Dahmen, J. et al., "2-Bromoethyl glycosides: applications in the synthesis of spacer-arm glycosides" Carbohydrate Research 118: 292-301 (1983).
Dahmen, J., et al., "Synthesis of space arm, lipid, and ethyl glycosides of the trisaccharide portion [.alpha.-D-Gal-(1-4)-.beta.-D-Gal(1-4)-.beta.-D-Glc] of the blood group p.sup.k antigen: preparation of neoglycoproteins" Carbohydrate Research 127: 15-25 (1984).
Ekborg, G. et al., "Synthesis of Three Disaccharides for the Preparation of Immunogens bearing Immunodeterminants Known to Occur on Glycoproteins" Carbohydrates Research 110: 55-67 (1982).
Ericsson, C.D. et al., "Travelers' Diarrhea: Approaches to prevention and treatment" Clin. Infect. Dis. 16: 616-626 (1993).
Fernandez-Santana, V. et al., "Glycosides of Monoallyl Diethylene Glycol. A New type of Spacer group for Synthetic Oligosaccharides" J. Carbohydrate Chemistry, 8(3): 531-537 (1989).
Fishman, P. H. et al., "Gangliosides as Receptors for Bacterial Enterotoxins" Advances in Lipid Research 25: 165-187 (1993).
Fugedi, P. et al., "Thioglycosides as Glycosylating Agents in Oligosaccharide Synthesis" Glycoconjugate J. 4: 97-108 (1987).
Fukuda et al Comparison of the carbohydrate-binding specificities of cholera toxin and Escherichia coli heat-labile enterotoxins Lth-I, LTh-IIa, and LTh-IIb Infect. Immun. 56: 1748-1753(1988).
Garegg, P. J. et al., "A Synthesis of 8-Methoxycarbonyloct-1-yl O-.alpha.-D-Galactopyranosyl-(1-3)-O-.beta.-D-Galactopyranosyl-(1-4)-2-Ace tamido-2-Deoxy-.beta.-D-Glucopyranoside" Carbohy. Res. 136: 207-213 (1985).
Garegg, P. J. et al., "Synthesis of 6- and 6' -deoxy derivatives of methyl 4-0-.alpha.-D-galactopyranosyl-.beta.-D-galactopyranoside for studies of inhibition of pyelonephritogenic fimbriated E. coli adhesion to urinary epithelium-cell surfaces" Carbohy. Res. 137: 270-275 (1985).
Heerze, L.D. et al., "Oligosaccharide sequences attached to an inert support (SYNSORB) as potential therapy for antibiotic-associated diarrhea and pseudomembranous colitis" J. Infect. Dis. 169: 1291-1296 (1994).
Huilan, S. et al., "Etiology of acute diarrhoea among children in developing countries--a multicenter study in five countries" Bulletin of the World Health Orgnisation 69: 549-55 (1991).
Jacquinet, J. C. et al., "Synthesis of Blood-group Substances, Part 11. Syn
Armstrong Glen D.
Heerze Louis D.
Synsorb Biotech Inc.
Wilson James O.
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