Proteins, their production and use

Details Proteins, their production and use Proteins, their production and use

1998-09-18

2000-05-30

Carlson, Karen Cochrane

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4352523, 4353201, 435219, 435226, 536 231, 536 235, 536 232, 530350, C12P 2100

Patent

active

060689900

ABSTRACT:
This invention relates to a novel calpain having a proteolytic activity, its partial peptide or a salt either of them, a DNA coding for the protein, a recombinant vector comprising the DNA, a transformant carrying the recombinant vector, a process for producing the protein, a pharmaceutical composition comprising the DNA, an antibody against the protein, a method for screening for a compound which activates or inhibits a proteolytic activity of the protein, a kit for screening for the compound, and a compound which activates or inhibits a proteolytic activity of the protein which is identified by the screening method or the kit. The DNA coding for the protein of the present invention can be used as a therapeutic and prophylactic composition for a variety of diseases including tumor, cerebral apoplexy, cerebral infarction, subarachnoid hemorrhage, Alzheimer's disease, myodystrophy, cataract, ischemic heart disease, atherosclerosis, arthritis, and collagen disease. Furthermore, the protein of the present invention is useful as a screening reagent for any compounds which activates or inhibits the function of the protein of the present invention. In addition, the antibody against the protein of the present invention specifically recognizes the protein of the present invention and can be used in the quantitative determination of the protein of the present invention in a test fluid.

REFERENCES:
patent: 5874277 (1999-02-01), Shintani et al.
Legendre et al. (1988) Inflammation 12/1, pp. 51-65.
Sorimachi et al. 1993) J. Biol. Chem. 90, pp. 19476-19482.
Database GenBank on STN, Accession No. A48764, Sorimachi et al.(1993).
Saito, et al., Proc. Natl. Acad. USA, vol. 90, (1993) pp. 2628-2632.
Sorimachi, et al., J. of Biol. Chem., vol. 90 (1993) pp. 19476-19482.
Legendre, et al., inflammation, vol. 12, No. 1, pp. 51-65 (1988).
Saido, et al., The FASEB Journal, vol. 8, pp. 814-822 (1994).

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