Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.
Patent
1992-04-27
1993-10-12
Moezie, F. T.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Hormones, e.g., prolactin, thymosin, growth factors, etc.
530324, 530325, 530326, 530327, 530328, 930 21, 930120, 930DIG530, C07K 1300, C07K 708, C07K 710, C07K 706
Patent
active
052527182
ABSTRACT:
Antagonists to basic fibroblast growth factor, a 146 amino acid residue polypeptide, are produced. These antagonists are generally between 10 and 45 residues in length and are characterized by their ability to interact with the FGF receptor and/or inhibit and therefore modulate endothelial and other cell growth in vitro and also in vivo. These antagonists includes the sequence of bovine basic FGF(106-115), namely Tyr-Arg-Ser-Arg-Lys-Tyr-Ser-Ser-Trp-Tyr or a sequence having equivalent residues substituted therein. These peptides are also antagonistic to acidic FGF and other members of the family of FGF peptides. They are effective to combat FGF-promoted mitosis in melanomas and the like.
REFERENCES:
patent: 4218474 (1990-08-01), Barnish
patent: 5132408 (1992-07-01), Baird
Rittle et al., Experientia, 37 (2), 246-248, 1976.
R. Kaner et al., Science, 248, 1410-1413, 1990.
Baird J. Andrew
Ling Nicholas C.
Moezie F. T.
The Salk Institute for Biological Studies
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