Antihypertensive benzopyran derivatives

Details Antihypertensive benzopyran derivatives Antihypertensive benzopyran derivatives

1992-08-26

1993-10-12

Springer, David B.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548454, 546113, C07D40704, A61K 3140

Patent

active

052525970

ABSTRACT:
Disclosed herein are novel benzopyrans represented by formula (I) ##STR1## wherein R.sup.1 is trifluoromethoxy or .beta.,.beta.,.beta.-trifluoroethoxy; R.sup.2, and R.sup.3 are independently selected from the group consisting of hydrogen, lower alkyl containing 1 to 5 carbon atoms, cyclo lower alkyl containing 5 to 8 carbon atoms, ##STR2## or R.sup.2 and R.sup.3 are joined to form (--CH.sub.2 --).sub.n wherein n is 4 to 7; or R.sup.2 and R.sup.3 are joined together to form (--CH.sub.2 --).sub.m CO-- wherein m is 3 to 6; or R.sup.2 and R.sup.3 are joined together to form ##STR3## wherein R.sup.4 is selected from the group consisting of hydrogen, alkoxy containing 1 to 5 carbon atoms, amino or mono- or disubstituted alkyl amino wherein said alkyl groups contain 1 to 5 carbon atoms and the pharmaceutically acceptable salts and solvates thereof, to a process for preparing them, to pharmaceutical compositions containing them, and to their use in the treatment of hypertension, asthma, imitable bladder syndrome, and irritable bowel syndrome.

REFERENCES:
patent: 4616021 (1986-10-01), Ashwood et al.

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