Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1997-12-22
2000-02-15
Mertz, Prema
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
536 235, 536 2431, C12Q 168, C12N 1512
Patent
active
060251387
ABSTRACT:
The present invention provides nucleotide and amino acid sequences that identify and encode the hyaluronan receptor (hr) from human umbilical vein endothelial cells. The present invention also provides for antisense molecules to the nucleotide sequences which encode hr, expression vectors for the production of purified HR, antibodies capable of binding specifically to HR, hybridization probes or oligonucleotides for detecting the upregulation of HR encoding nucleotide sequences, genetically engineered host cells for the expression of HR, diagnostic tests for activated, angiogenic, inflamed or metastatic cells and/or tissues based on HR-encoding nucleic acid molecules and antibodies capable of binding specifically to the receptor.
REFERENCES:
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McCourt, P.A.G. et al., "Intercellular Adhesion Molecule-1 Is a Cell Surface Receptor for Hyaluronan", The Journal of Biological Chemistry, 269:30081-30084 (1994).
Jaworski, D.M. et al., "BEHAB, a New Member of the Proteoglycan Tandem Repeat Family of Hyaluronan-binding Proteins That is Restricted to the Brain", The Journal of Cell Biology 125:495-509 (1994).
Lee, T.H. et al., "A Novel Secretory Tumor Necrosis Factor-inducible Protein (TSG-6) Is a Member of the Family of Hyaluronate Binding Proteins, Closely Related to the Adhesion Receptor CD44" Journal of Cell Biology, 116: 545-557 (1992).
Hawkins Phillip R.
Seilhamer Jeffrey J.
Wilde Craig G.
Incyte Pharmaceuticals Inc.
Mertz Prema
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