Human succinyl-coenzyme a synthetase holoenzyme

Details Human succinyl-coenzyme a synthetase holoenzyme Human succinyl-coenzyme a synthetase holoenzyme

1999-02-25

2000-02-15

Achutamurthy, Ponnathapu

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

435183, 424 945, C12Q 100, C12N 900, A61K 3851

Patent

active

060251239

ABSTRACT:
The invention provides human succinyl-CoA synthetase holoenzyme (SCSH) and polynucleotides which identify and encode SCSH. The invention also provides expression sectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of SCSH.

REFERENCES:
Um, H.D., and Klein, C., Evidence for Allosteric Regulation of Succinyl-CoA Synthetase, Biochem. J., 295:821-826, (1993).
Collier, G.E. and Nishimura, J.S., Affinity Labeling of Succinyl-CoA Synthetase from Porcine Heart and Escherichia coli with Oxidized Coenzyme A Disulfide, J. Biol. Chem., 253:4938-4943, (1978).
Gougoux, A., et al., Effect of Acetazolamide on Renal Metabolism and Ammoniagenesis in the Dog, Kidney Int., 31:1279-1290, (1987).
Srere, P.A., Citric Acid Cycle, Methods in Enzymology, 13:3-11, (1969).

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