N-Hydroxy-1,2-dihydro-2-oxo-5-(pyridinyl)-nicotinimidamide and t

Details N-Hydroxy-1,2-dihydro-2-oxo-5-(pyridinyl)-nicotinimidamide and t N-Hydroxy-1,2-dihydro-2-oxo-5-(pyridinyl)-nicotinimidamide and t

1980-12-22

1981-12-15

Raymond, Richard

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546257, A61K 3144, C07D40104

Patent

active

043059481

ABSTRACT:
N-Hydroxy-1-R.sub.1 -1,2-dihydro-2-oxo-5-PY-6-R-nicotinimidamides or pharmaceutically-acceptable acid-addition salts thereof, useful as cardiotonic agents, are prepared by reacting 1-R.sub.1 -1,2-dihydro-2-oxo-5-PY-6-R-nicotinonitriles with hydroxylamine and are converted by reaction with polyphosphoric acid to the corresponding cardiotonically useful 1-R.sub.1 -3-amino-5-PY-6-R-2(1H)-pyridinones, where R.sub.1 is hydrogen, lower-alkyl and lower-hydroxyalkyl, R is hydrogen or lower-alkyl, and PY is 4- or 3-pyridinyl or 4- or 3-pyridinyl having one or two lower-alkyl substituents.

REFERENCES:
patent: 4004012 (1977-01-01), Lesher et al.
patent: 4072746 (1978-02-01), Lesher et al.

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