Process for the preparation of defective mutants of microorganis

Details Process for the preparation of defective mutants of microorganis Process for the preparation of defective mutants of microorganis

1980-03-07

1982-12-07

Tanenholtz, Alvin E.

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

435253, 435 55, C12N 1500, C12N 120, C12P 3316

Patent

active

043628150

ABSTRACT:
For the production of 17-C-steroid-.alpha.-propionic acid compounds by microbial side chain degradation on 17-C-side chain steroid substrates wild strain microorganisms selected in predetermined manner are subjected to a multi-stage mutation and selection. The resultant mutant strains are capable of supplying the desired compounds, e.g. .DELTA.-4 BNC and/or .DELTA.-1,4 BNC in high yields even in the absence of inhibitors arresting the growth and/or degradation of the steroid ring. Wild strains and mutants particularly suitable, and their choice, production and use, are described.

REFERENCES:
patent: 3759791 (1973-09-01), Marshecki et al.
patent: 4029549 (1977-06-01), Antosz et al.
patent: 4032408 (1977-06-01), Jin et al.
patent: 4062729 (1977-12-01), Biggs et al.
Lamanna et al., Basic Bacteriology, Its Biological and Chemical Background, 3rd Ed., The Williams & Wilkins Co., pp. 723-727, (1965).
Metzler, Biochemistry, The Chemical Reactions of Living Cells, Academic Press Inc., pp. 945 and 946, (1977).
Whitmarsh, The Biochemical Journal, vol. 90, pp. 23p and 24p, (1964).
Martin et al., European J. Appl. Microbial, vol. 2, pp. 243-255, (1976).

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